PMID- 19338586
OWN - NLM
STAT- MEDLINE
DCOM- 20090805
LR  - 20171116
IS  - 1600-0536 (Electronic)
IS  - 0105-1873 (Linking)
VI  - 60
IP  - 4
DP  - 2009 Apr
TI  - Skin sensitization potency and cross-reactivity of p-phenylenediamine and its 
      derivatives evaluated by non-radioactive murine local lymph node assay and 
      guinea-pig maximization test.
PG  - 193-8
LID - 10.1111/j.1600-0536.2008.01500.x [doi]
AB  - BACKGROUND: p-Phenylenediamine (PPD)-related chemicals have been used as 
      antioxidants in rubber products, and many cases of contact dermatitis caused by 
      these chemicals have been reported. OBJECTIVE: The aim of this study was to 
      investigate relative sensitizing potency and cross-reactivity among PPD 
      derivatives. METHODS: Five PPD derivatives, p-aminodiphenylamine (PADPA), 
      N,N'-diphenyl-p-phenylenediamine (DPPD), N-isopropyl-N'-phenyl-p-phenylenediamine 
      (IPPD), N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (DMBPPD), 
      N-(1-methylheptyl)-N'-phenyl-p-phenylenediamine (MHPPD), and the core chemical 
      PPD were evaluated for their sensitizing potency and cross-reactivity using the 
      non-radioactive murine local lymph node assay (LLNA) and the guinea-pig 
      maximization test (GPMT). RESULTS: PPD and all the derivatives were identified as 
      primary sensitizers in both tests. The order of potency in the LLNA was as 
      follows: IPPD and PADPA > PPD > DMBPPD and MHPPD > DPPD. In the GPMT, all six 
      groups of animals sensitized with one of these chemicals cross-reacted to four 
      other derivatives. Specifically, the five groups that have a common basic PADPA 
      structure, that is PADPA, DPPD, IPPD, DMBPPD, and MHPPD, all reacted to each 
      other at almost the same scores, while none of them reacted to PPD. CONCLUSIONS: 
      The cross-reactivity profile found in the study was to some extent different from 
      that in previous human data, where distinction between cross-reaction and 
      concomitant primary sensitization is not always clear.
FAU - Yamano, Tetsuo
AU  - Yamano T
AD  - Food and Health Science Group, Osaka City Institute of Public Health and 
      Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan. 
      te-yamano@city.osaka.lg.jp
FAU - Shimizu, Mitsuru
AU  - Shimizu M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Allergens)
RN  - 0 (Phenylenediamines)
RN  - 007X4XXS71 (4-aminodiphenylamine)
RN  - DD517SCM92 (N,N'-diphenyl-4-phenylenediamine)
RN  - E0FUI016V7 (N-isopropyl-N-phenyl-4-phenylenediamine)
RN  - HJD0U67PS1 (N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine)
RN  - U770QIT64J (4-phenylenediamine)
SB  - IM
MH  - Allergens/administration & dosage/*toxicity
MH  - Animals
MH  - Cross Reactions
MH  - Dermatitis, Contact/*diagnosis/epidemiology/*immunology
MH  - Dose-Response Relationship, Drug
MH  - Guinea Pigs
MH  - Local Lymph Node Assay
MH  - Lymph Nodes/*drug effects
MH  - Mice
MH  - Phenylenediamines/chemistry/*toxicity
MH  - Reference Standards
MH  - Sensitivity and Specificity
EDAT- 2009/04/03 09:00
MHDA- 2009/08/06 09:00
CRDT- 2009/04/03 09:00
PHST- 2009/04/03 09:00 [entrez]
PHST- 2009/04/03 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
AID - COD1500 [pii]
AID - 10.1111/j.1600-0536.2008.01500.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2009 Apr;60(4):193-8. doi: 10.1111/j.1600-0536.2008.01500.x.