PMID- 19338590
OWN - NLM
STAT- MEDLINE
DCOM- 20090805
LR  - 20090402
IS  - 1600-0536 (Electronic)
IS  - 0105-1873 (Linking)
VI  - 60
IP  - 4
DP  - 2009 Apr
TI  - Occupational contact urticaria caused by cyclic acid anhydrides.
PG  - 214-21
LID - 10.1111/j.1600-0536.2009.01526.x [doi]
AB  - BACKGROUND: Cyclic acid anhydrides often cause allergic respiratory diseases, but 
      contact urticaria because of these anhydrides has been considered rare. 
      OBJECTIVE: We describe 21 patients diagnosed with occupational contact urticaria 
      at the Finnish Institute of Occupational Health during the period 1990-2006. 
      METHOD: Prick test with human serum albumin (HSA)-acid anhydride conjugates, 
      determination of specific immunoglobulin E (IgE), and open application were used 
      in the diagnosis. RESULTS: The majority of the patients worked in the manufacture 
      of electrical machines and were exposed to an epoxy hardener containing methyl 
      hexahydrophthalic anhydride. The largest prick test reaction was often noted for 
      the acid anhydride the patient had been exposed to. The specific IgE results were 
      mostly in line with the prick test reactions. Phthalic anhydride IgE was 
      determined in 20 patients and was found positive in 19 patients. In open 
      application, a positive test result often required the use of the undiluted 
      hardener. CONCLUSIONS: Contact urticaria may be more common than previously 
      believed. Prick tests with HSA-acid anhydride conjugates were a useful test 
      method for detecting immediate sensitization to acid anhydrides. The 
      determination of the specific IgE gave almost equal results. The open application 
      test often had to be performed with the undiluted anhydride product to obtain a 
      positive test result.
FAU - Helaskoski, Eva
AU  - Helaskoski E
AD  - Department of Occupational Medicine, Finnish Institute of Ocuupational Health, 
      Helsinki, Finland. eva.helaskoski@ttl.fi
FAU - Kuuliala, Outi
AU  - Kuuliala O
FAU - Aalto-Korte, Kristiina
AU  - Aalto-Korte K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Anhydrides)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Air Pollutants, Occupational/toxicity
MH  - Anhydrides/*adverse effects
MH  - Dermatitis, Occupational/blood/*diagnosis/*etiology
MH  - Female
MH  - Finland
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/*adverse effects
MH  - Retrospective Studies
MH  - Skin Tests
MH  - Urticaria/blood/*chemically induced/*diagnosis
EDAT- 2009/04/03 09:00
MHDA- 2009/08/06 09:00
CRDT- 2009/04/03 09:00
PHST- 2009/04/03 09:00 [entrez]
PHST- 2009/04/03 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
AID - COD1526 [pii]
AID - 10.1111/j.1600-0536.2009.01526.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2009 Apr;60(4):214-21. doi: 10.1111/j.1600-0536.2009.01526.x.