PMID- 19339597
OWN - NLM
STAT- MEDLINE
DCOM- 20090423
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 13
DP  - 2009 Apr 1
TI  - BDNF exerts contrasting effects on peripheral myelination of NGF-dependent and 
      BDNF-dependent DRG neurons.
PG  - 4016-22
LID - 10.1523/JNEUROSCI.3811-08.2009 [doi]
AB  - Although brain-derived neurotrophic factor (BDNF) has been shown to promote 
      peripheral myelination during development and remyelination after injury, the 
      precise mechanisms mediating this effect remain unknown. Here, we determine that 
      BDNF promotes myelination of nerve growth factor-dependent neurons, an effect 
      dependent on neuronal expression of the p75 neurotrophin receptor, whereas BDNF 
      inhibits myelination of BDNF-dependent neurons via the full-length TrkB receptor. 
      Thus, BDNF exerts contrasting effects on Schwann cell myelination, depending on 
      the complement of BDNF receptors that are expressed by different subpopulations 
      of dorsal root ganglion neurons. These results demonstrate that BDNF exerts 
      contrasting modulatory roles in peripheral nervous system myelination, and that 
      its mechanism of action is acutely regulated and specifically targeted to 
      neurons.
FAU - Xiao, Junhua
AU  - Xiao J
AD  - Neurotrophin Signaling Laboratory, Centre for Neuroscience, Florey Neuroscience 
      Institutes, The University of Melbourne, Melbourne, Victoria 3010, Australia.
FAU - Wong, Agnes W
AU  - Wong AW
FAU - Willingham, Melanie M
AU  - Willingham MM
FAU - Kaasinen, Selma K
AU  - Kaasinen SK
FAU - Hendry, Ian A
AU  - Hendry IA
FAU - Howitt, Jason
AU  - Howitt J
FAU - Putz, Ulrich
AU  - Putz U
FAU - Barrett, Graham L
AU  - Barrett GL
FAU - Kilpatrick, Trevor J
AU  - Kilpatrick TJ
FAU - Murray, Simon S
AU  - Murray SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Myelin P0 Protein)
RN  - 0 (Myelin Proteins)
RN  - 0 (Myelin-Associated Glycoprotein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 136958-07-1 (Ngfr protein, rat)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - 97161-97-2 (staurosporine aglycone)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*physiology
MH  - Carbazoles/pharmacology
MH  - Cells, Cultured
MH  - Coculture Techniques/methods
MH  - Enzyme Inhibitors/pharmacology
MH  - Ganglia, Spinal/*cytology
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Indole Alkaloids/pharmacology
MH  - Mice
MH  - Myelin Basic Protein/metabolism
MH  - Myelin P0 Protein/metabolism
MH  - Myelin Proteins/*metabolism
MH  - Myelin-Associated Glycoprotein/metabolism
MH  - Nerve Growth Factor/pharmacology/*physiology
MH  - Nerve Tissue Proteins/genetics
MH  - Neurons/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Growth Factor/genetics
MH  - Receptors, Nerve Growth Factor/genetics
MH  - Schwann Cells/drug effects
MH  - Tissue Culture Techniques
MH  - Transfection
PMC - PMC6665359
EDAT- 2009/04/03 09:00
MHDA- 2009/04/25 09:00
PMCR- 2009/10/01
CRDT- 2009/04/03 09:00
PHST- 2009/04/03 09:00 [entrez]
PHST- 2009/04/03 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
PHST- 2009/10/01 00:00 [pmc-release]
AID - 29/13/4016 [pii]
AID - 3470020 [pii]
AID - 10.1523/JNEUROSCI.3811-08.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Apr 1;29(13):4016-22. doi: 10.1523/JNEUROSCI.3811-08.2009.