PMID- 19339612
OWN - NLM
STAT- MEDLINE
DCOM- 20090423
LR  - 20231213
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 13
DP  - 2009 Apr 1
TI  - Vasculature guides migrating neuronal precursors in the adult mammalian forebrain 
      via brain-derived neurotrophic factor signaling.
PG  - 4172-88
LID - 10.1523/JNEUROSCI.4956-08.2009 [doi]
AB  - Adult neuronal precursors retain the remarkable capacity to migrate long 
      distances from the posterior (subventricular zone) to the most anterior 
      [olfactory bulb (OB)] parts of the brain. The knowledge about the mechanisms that 
      keep neuronal precursors in the migratory stream and organize this long-distance 
      migration is incomplete. Here we show that blood vessels precisely outline the 
      migratory stream for new neurons in the adult mammalian forebrain. Real-time 
      video imaging of cell migration in the acute slices demonstrate that neuronal 
      precursors are retained in the migratory stream and guided into the OB by blood 
      vessels that serve as a physical substrate for migrating neuroblasts. Our data 
      suggest that endothelial cells of blood vessels synthesize brain-derived 
      neurotrophic factor (BDNF) that fosters neuronal migration via p75NTR expressed 
      on neuroblasts. Interestingly, GABA released from neuroblasts induces 
      Ca(2+)-dependent insertion of high-affinity TrkB receptors on the plasma membrane 
      of astrocytes that trap extracellular BDNF. We hypothesize that this renders BDNF 
      unavailable for p75NTR-expressing migrating cells and leads to their entrance 
      into the stationary period. Our findings provide new insights into the functional 
      organization of substrates that facilitate the long-distance journey of adult 
      neuronal precursors.
FAU - Snapyan, Marina
AU  - Snapyan M
AD  - The Cellular Neurobiology Unit, Centre de Recherche Universite Laval 
      Robert-Giffard, Quebec, Quebec, Canada G1J 2G3.
FAU - Lemasson, Morgane
AU  - Lemasson M
FAU - Brill, Monika S
AU  - Brill MS
FAU - Blais, Mathieu
AU  - Blais M
FAU - Massouh, Mireille
AU  - Massouh M
FAU - Ninkovic, Jovica
AU  - Ninkovic J
FAU - Gravel, Claude
AU  - Gravel C
FAU - Berthod, Francois
AU  - Berthod F
FAU - Gotz, Magdalena
AU  - Gotz M
FAU - Barker, Philip A
AU  - Barker PA
FAU - Parent, Andre
AU  - Parent A
FAU - Saghatelyan, Armen
AU  - Saghatelyan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Boron Compounds)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Transporter 1)
RN  - 0 (GABA Antagonists)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Platelet Endothelial Cell Adhesion Molecule-1)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Slc1a3 protein, mouse)
RN  - 0 (Ngfr protein, mouse)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - E4ES684O93 (2-aminoethoxydiphenyl borate)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 1)
RN  - G34N38R2N1 (Bromodeoxyuridine)
RN  - SY7Q814VUP (Calcium)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Adult Stem Cells/*physiology
MH  - Animals
MH  - Astrocytes
MH  - Bicuculline/pharmacology
MH  - Blood Vessels/*physiology
MH  - Boron Compounds/pharmacology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - Calcium/metabolism
MH  - Cell Movement/genetics/*physiology
MH  - Cells, Cultured
MH  - Endothelial Cells/physiology
MH  - Excitatory Amino Acid Transporter 1/genetics
MH  - Flow Cytometry/methods
MH  - GABA Antagonists/pharmacology
MH  - Gene Expression/physiology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Glutamate Decarboxylase/deficiency
MH  - Green Fluorescent Proteins/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Microscopy, Video/methods
MH  - Neurons/drug effects/*physiology
MH  - Platelet Endothelial Cell Adhesion Molecule-1/metabolism
MH  - Prosencephalon/cytology/*physiology
MH  - Protein Transport/drug effects
MH  - RNA, Small Interfering/pharmacology
MH  - Receptor, trkB/metabolism
MH  - Receptors, Nerve Growth Factor/deficiency
MH  - Signal Transduction/genetics/*physiology
MH  - Tissue Culture Techniques
MH  - gamma-Aminobutyric Acid/pharmacology
PMC - PMC6665362
EDAT- 2009/04/03 09:00
MHDA- 2009/04/25 09:00
PMCR- 2009/10/01
CRDT- 2009/04/03 09:00
PHST- 2009/04/03 09:00 [entrez]
PHST- 2009/04/03 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
PHST- 2009/10/01 00:00 [pmc-release]
AID - 29/13/4172 [pii]
AID - 3470022 [pii]
AID - 10.1523/JNEUROSCI.4956-08.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Apr 1;29(13):4172-88. doi: 10.1523/JNEUROSCI.4956-08.2009.