PMID- 19341740
OWN - NLM
STAT- MEDLINE
DCOM- 20090821
LR  - 20131121
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 56
IP  - 1
DP  - 2009 Jun
TI  - Maternal postpartum learned helplessness (LH) affects maternal care by dams and 
      responses to the LH test in adolescent offspring.
PG  - 112-20
LID - 10.1016/j.yhbeh.2009.03.016 [doi]
AB  - It is known that the early environment affects the mental development of rodent 
      and human offspring. However, it is not known specifically whether a postpartum 
      depressive state influences the depressive state in offspring. Using learned 
      helplessness (LH) in rats as an animal model of depression, we examined the 
      influence of maternal postpartum LH on responses to the LH test of offspring. Dam 
      rats were judged as LH or non-helpless (nLH) on postnatal days (PN) 2-3, and 
      maternal behavior was recorded during PN2-14. On PN 45-46, offspring were 
      subjected to the LH test. Plasma corticosterone (CORT) levels, hippocampal levels 
      of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) mRNA 
      were measured before and after the LH test in offspring. Active nursing in LH 
      dams was significantly lower than that in nLH dams. Susceptibility to LH in the 
      offspring of LH dams was significantly higher than in those of nLH dams, and was 
      negatively correlated with active nursing by LH dams. The GR mRNA levels before 
      and after the LH test were lower in the offspring of LH dams than in those of nLH 
      dams, and the reduced basal GR mRNA and protein might have resulted in the higher 
      CORT response after the LH test. There was no significant difference in BDNF mRNA 
      in the offspring of LH and nLH dams. These findings suggest that early postpartum 
      LH decreased active nursing and increased depression-like behavior in the 
      adolescent offspring via dysfunction of the hypothalamic-pituitary-adrenal axis.
FAU - Kurata, Akiko
AU  - Kurata A
AD  - Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, 
      Programs for Biomedical Research, Graduate School of Biomedical Sciences, 
      Hiroshima University, Minami-ku, Hiroshima, Japan.
FAU - Morinobu, Shigeru
AU  - Morinobu S
FAU - Fuchikami, Manabu
AU  - Fuchikami M
FAU - Yamamoto, Shigeto
AU  - Yamamoto S
FAU - Yamawaki, Shigeto
AU  - Yamawaki S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090331
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Glucocorticoid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anxiety/psychology
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Breast Feeding/psychology
MH  - Corticosterone/blood
MH  - Depression/psychology
MH  - Exploratory Behavior
MH  - Female
MH  - *Helplessness, Learned
MH  - Hippocampus/metabolism
MH  - Male
MH  - Maternal Behavior/physiology/*psychology
MH  - Maze Learning
MH  - Motor Activity
MH  - Postpartum Period/*psychology
MH  - RNA, Messenger/metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Glucocorticoid/metabolism
EDAT- 2009/04/04 09:00
MHDA- 2009/08/22 09:00
CRDT- 2009/04/04 09:00
PHST- 2008/09/24 00:00 [received]
PHST- 2009/03/17 00:00 [revised]
PHST- 2009/03/19 00:00 [accepted]
PHST- 2009/04/04 09:00 [entrez]
PHST- 2009/04/04 09:00 [pubmed]
PHST- 2009/08/22 09:00 [medline]
AID - S0018-506X(09)00082-8 [pii]
AID - 10.1016/j.yhbeh.2009.03.016 [doi]
PST - ppublish
SO  - Horm Behav. 2009 Jun;56(1):112-20. doi: 10.1016/j.yhbeh.2009.03.016. Epub 2009 
      Mar 31.