PMID- 19341776
OWN - NLM
STAT- MEDLINE
DCOM- 20090828
LR  - 20090610
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 47
IP  - 7
DP  - 2009 Jul
TI  - The neuroprotective effects of the seeds of Cassia obtusifolia on transient 
      cerebral global ischemia in mice.
PG  - 1473-9
LID - 10.1016/j.fct.2009.03.028 [doi]
AB  - The aim of this study was to determine the mechanism underlying the 
      neuroprotective effects of the ethanolic extract of the seeds of Cassia 
      obtusifolia (COE) (10 or 50mg/kg/day, p.o) on transient cerebral global ischemia 
      induced by bilateral common carotid artery occlusion (2VO) in mice. 
      Immunohistochemical and western blot studies showed that levels of inducible 
      nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hippocampal CA1 
      region at 1day post-2VO were attenuated by COE (50mg/kg/day, p.o), which was 
      administered immediately after 2VO. Furthermore, OX-42 - and glial fibrillary 
      acidic protein (GFAP)-positive cell numbers at 4 days post-2VO were markedly 
      attenuated by COE (50mg/kg/day, p.o) treatment for 4 days in CA1. Viable neurons 
      detected by Nissl at 7 days post-2VO were increased by administering COE 
      (50mg/kg/day, p.o) for 7 days. In addition, COE increased the expressions of 
      phosphorylated cAMP response element binding protein (CREB) and brain-derived 
      neurotrophic factor (BDNF) in CA1 in naive-control within 1 and 6h, respectively, 
      and these expressions were also profoundly increased in 2VO-treated mice by COE 
      at immediately post-2VO. These results suggest that the neuroprotective effects 
      of COE are due to its anti-inflammatory effects and to its upregulation of BDNF 
      expression and CREB phosphorylation.
FAU - Kim, Dong Hyun
AU  - Kim DH
AD  - Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, #1 
      Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Republic of Korea.
FAU - Kim, Sunho
AU  - Kim S
FAU - Jung, Won Yong
AU  - Jung WY
FAU - Park, Se Jin
AU  - Park SJ
FAU - Park, Dong Hyun
AU  - Park DH
FAU - Kim, Jong Min
AU  - Kim JM
FAU - Cheong, Jae Hoon
AU  - Cheong JH
FAU - Ryu, Jong Hoon
AU  - Ryu JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090331
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Animals
MH  - Arterial Occlusive Diseases/pathology
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Carotid Arteries/physiology
MH  - Cassia/*chemistry
MH  - Cell Survival/drug effects
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Cyclooxygenase 2/metabolism
MH  - Hippocampus/enzymology/metabolism/pathology
MH  - Immunohistochemistry
MH  - Ischemic Attack, Transient/*drug therapy/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neuroglia/pathology
MH  - Neuroprotective Agents/isolation & purification/*therapeutic use
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Plant Extracts/therapeutic use
MH  - Seeds/chemistry
EDAT- 2009/04/04 09:00
MHDA- 2009/08/29 09:00
CRDT- 2009/04/04 09:00
PHST- 2008/07/23 00:00 [received]
PHST- 2009/03/11 00:00 [revised]
PHST- 2009/03/24 00:00 [accepted]
PHST- 2009/04/04 09:00 [entrez]
PHST- 2009/04/04 09:00 [pubmed]
PHST- 2009/08/29 09:00 [medline]
AID - S0278-6915(09)00141-0 [pii]
AID - 10.1016/j.fct.2009.03.028 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2009 Jul;47(7):1473-9. doi: 10.1016/j.fct.2009.03.028. Epub 
      2009 Mar 31.