PMID- 19341782
OWN - NLM
STAT- MEDLINE
DCOM- 20090819
LR  - 20131121
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 161
IP  - 2
DP  - 2009 Jun 30
TI  - The organization of feedback projections in a pathway important for processing 
      pheromonal signals.
PG  - 489-500
LID - 10.1016/j.neuroscience.2009.03.065 [doi]
AB  - In most of the mammalian sensory systems there are massive cortical feedback 
      projections to early processing stations. The mammalian accessory olfactory 
      system is considered unique in several aspects. It is specialized for processing 
      pheromonal signals and plays a critical role in regulating sociosexual behaviors. 
      Furthermore, pheromonal signals are believed to bypass cortex and reach the 
      hypothalamic behavioral centers after merely three forward projections. Because 
      the organization of the feedback projections in the accessory olfactory system 
      remains largely unclear, the importance of the feedback projections in the 
      processing of pheromonal signals has been ignored. Here we show that in mice the 
      feedback projections from the bed nucleus of stria terminalis (BST) and the 
      vomeronasal amygdala to the accessory olfactory bulb (AOB) are topographically 
      organized and use different neurotransmitters. By retrograde and anterograde 
      tracing, we find that the feedback projection from the BST terminates in the AOB 
      mitral cell layer, whereas that from the amygdala terminates in the AOB granule 
      cell layer. By combining tracing, genetic labeling of GABAergic neurons, and 
      immunostaining against a marker of glutamatergic synapses, we observe that the 
      BST-to-AOB projection is GABAergic whereas the amygdala-to-AOB projection is 
      glutamatergic. In addition, a substantial number of feedback neurons in the 
      amygdala and BST express estrogen receptors. Thus, the accessory olfactory 
      system, like other sensory systems, possesses extensive feedback projections. 
      Moreover, our results suggest that central hormonal cues may modulate the 
      processing of pheromonal signals at early stations through the precisely 
      organized feedback projections.
FAU - Fan, S
AU  - Fan S
AD  - Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
FAU - Luo, M
AU  - Luo M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090331
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Pheromones)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 1)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Estrogen Receptor alpha/biosynthesis
MH  - *Feedback
MH  - Glutamate Decarboxylase/genetics
MH  - Glutamic Acid/physiology
MH  - Green Fluorescent Proteins/genetics
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - *Neural Pathways
MH  - Neurons/metabolism
MH  - Neurotransmitter Agents/physiology
MH  - Olfactory Bulb/cytology/*physiology
MH  - Pheromones/*physiology
MH  - Septal Nuclei/cytology/*physiology
MH  - Vomeronasal Organ/*physiology
MH  - gamma-Aminobutyric Acid/physiology
EDAT- 2009/04/04 09:00
MHDA- 2009/08/20 09:00
CRDT- 2009/04/04 09:00
PHST- 2009/02/17 00:00 [received]
PHST- 2009/03/23 00:00 [revised]
PHST- 2009/03/23 00:00 [accepted]
PHST- 2009/04/04 09:00 [entrez]
PHST- 2009/04/04 09:00 [pubmed]
PHST- 2009/08/20 09:00 [medline]
AID - S0306-4522(09)00492-8 [pii]
AID - 10.1016/j.neuroscience.2009.03.065 [doi]
PST - ppublish
SO  - Neuroscience. 2009 Jun 30;161(2):489-500. doi: 
      10.1016/j.neuroscience.2009.03.065. Epub 2009 Mar 31.