PMID- 1934423
OWN - NLM
STAT- MEDLINE
DCOM- 19911216
LR  - 20061115
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 84
IP  - 5 Suppl
DP  - 1991 Nov
TI  - Survival improvement with dynamic cardiomyoplasty in patients with dilated 
      cardiomyopathy.
PG  - III296-302
AB  - Surgical support to the failing heart has been investigated in the treatment of 
      severe myocardial failure. Dynamic cardiomyoplasty was indicated in 32 patients 
      with dilated or chagasic cardiomyopathy who were in New York Heart Association 
      (NYHA) class III or IV despite maximum medical therapy. Fifteen patients were 
      operated on, and 17 refused the surgical treatment and were maintained by 
      clinical means. With an average follow-up period of 12.3 months, actuarial 
      survival rates for cardiomyoplasty patients were 86.6% at 6 months, 78.7% at 1 
      year, and 65.6% at 2 years of follow-up, whereas patients under medical therapy 
      presented survival rates of 58.8%, 41.1%, and 27.4% at the same periods, 
      respectively (p = 0.03). Furthermore, five of the 11 surviving patients of the 
      cardiomyoplasty group are in NYHA class I, five in class II, and one in class 
      III. At 6 months of cardiomyoplasty follow-up, rest radioisotopic left 
      ventricular ejection fraction increased from 20.1 +/- 3.9% to 26.8 +/- 7.5% (p 
      less than 0.01). Cardiopulmonary exercise testing showed that maximum oxygen 
      consumption during treadmill testing improved from 14.7 +/- 3.9 to 18.3 +/- 3.9 
      ml/kg/min (p = 0.01). At 1 year of follow-up, these data remained essentially 
      unchanged. In conclusion, dynamic cardiomyoplasty reverses congestive heart 
      failure and improves the long-term survival of patients with severe 
      cardiomyopathies.
FAU - Moreira, L F
AU  - Moreira LF
AD  - Instituto do Coracao Faculdade de Medicina, Universidade de Sao Paulo, Brazil.
FAU - Seferian, P Jr
AU  - Seferian P Jr
FAU - Bocchi, E A
AU  - Bocchi EA
FAU - Pego-Fernandes, P M
AU  - Pego-Fernandes PM
FAU - Stolf, N A
AU  - Stolf NA
FAU - Pereira-Barretto, A C
AU  - Pereira-Barretto AC
FAU - Jatene, A D
AU  - Jatene AD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Adult
MH  - Assisted Circulation/*methods
MH  - Cardiomyopathy, Dilated/drug therapy/*mortality/surgery
MH  - Chagas Cardiomyopathy/drug therapy/*mortality/surgery
MH  - Electric Stimulation Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Muscles/*transplantation
MH  - Surgical Flaps
EDAT- 1991/11/11 19:15
MHDA- 2001/03/28 10:01
CRDT- 1991/11/11 19:15
PHST- 1991/11/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1991/11/11 19:15 [entrez]
PST - ppublish
SO  - Circulation. 1991 Nov;84(5 Suppl):III296-302.