PMID- 19346698
OWN - NLM
STAT- MEDLINE
DCOM- 20090514
LR  - 20190606
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 71
IP  - 3
DP  - 2009 Mar
TI  - Expression of macrophage metalloelastase (MMP-12) in podocytes of hereditary 
      nephrotic mice (ICGN strain).
PG  - 305-12
AB  - The Institute for Cancer Research (ICR)-derived glomerulonephritis (ICGN) mouse 
      is a good model for renal fibrosis. In the glomeruli and tubulointerstitium of 
      ICGN mouse kidneys, the components of the extracellular matrix (ECM) accumulated, 
      and matrix metalloproteinases (MMPs) participated in this process. To clarify the 
      mechanism of renal fibrosis, we investigated the expression and localization of 
      macrophage metalloelastase (MMP-12), whose functions in kidney diseases are not 
      fully understood, and its regulatory molecules, monocyte chemoattractive 
      protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2), in the kidneys of ICGN mice 
      by RT-PCR, Western blotting and immunohistochemical staining, respectively. 
      Extensive expression of MMP-12 mRNA and its protein was noted in ICGN mice with 
      progressed nephrotic syndrome. The increase in MMP-12 expression occurred 
      predominantly in podocytes. Furthermore, MCP-1 and CCR2 were also increased in 
      podocytes of the ICGN strain. These results suggest that the expression of MMP-12 
      is involved in the progression of nephrotic syndrome in ICGN mice.
FAU - Uchio, Kozue
AU  - Uchio K
AD  - Laboratory of Experimental Animal Models, National Institute of Biomedical 
      Innovation, Ibaraki, Osaka, Japan. kozue-mt@nibio.go.jp
FAU - Sawada, Kyoko
AU  - Sawada K
FAU - Manabe, Noboru
AU  - Manabe N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - EC 3.4.24.65 (Matrix Metalloproteinase 12)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Enzymologic/*physiology
MH  - Matrix Metalloproteinase 12/*metabolism
MH  - Mice
MH  - Nephritis, Hereditary/*genetics/*metabolism/pathology
MH  - Podocytes/*enzymology
EDAT- 2009/04/07 09:00
MHDA- 2009/05/15 09:00
CRDT- 2009/04/07 09:00
PHST- 2009/04/07 09:00 [entrez]
PHST- 2009/04/07 09:00 [pubmed]
PHST- 2009/05/15 09:00 [medline]
AID - JST.JSTAGE/jvms/71.305 [pii]
AID - 10.1292/jvms.71.305 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2009 Mar;71(3):305-12. doi: 10.1292/jvms.71.305.