PMID- 19347323
OWN - NLM
STAT- MEDLINE
DCOM- 20090520
LR  - 20090617
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 531
DP  - 2009
TI  - Identification of pathogen receptors on dendritic cells to understand their 
      function and to identify new drug targets.
PG  - 267-85
LID - 10.1007/978-1-59745-396-7_17 [doi]
AB  - Dendritic cells (DCs) are crucial in the defence against invading pathogens. 
      These professional antigen-presenting cells express a diversity of pattern 
      recognition receptors to recognize pathogens and to induce adaptive immune 
      responses. However, pathogens have also developed several mechanisms to suppress 
      or modulate DC function through specific receptors, thereby ensuring pathogen 
      survival and dissemination. In this chapter, we will discuss techniques to 
      identify and functionally characterize pathogen receptors on DCs and to determine 
      whether DCs elicit protective immune responses or whether pathogens subvert these 
      responses to escape immunity.
FAU - de Witte, Lot
AU  - de Witte L
AD  - Department of Molecular Cell Biology & Immunology, VU University Medical Center, 
      Amsterdam, The Netherlands.
FAU - de Jong, Marein A W P
AU  - de Jong MA
FAU - den Dunnen, Jeroen
AU  - den Dunnen J
FAU - van Kooyk, Yvette
AU  - van Kooyk Y
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Bacteria
MH  - Dendritic Cells/*microbiology/*virology
MH  - *Drug Design
MH  - Hybridomas
MH  - Mice
MH  - Microspheres
MH  - Molecular Biology/*methods
MH  - Receptors, Cell Surface/*metabolism
MH  - Saccharomyces cerevisiae
MH  - Viruses
EDAT- 2009/04/07 09:00
MHDA- 2009/05/21 09:00
CRDT- 2009/04/07 09:00
PHST- 2009/04/07 09:00 [entrez]
PHST- 2009/04/07 09:00 [pubmed]
PHST- 2009/05/21 09:00 [medline]
AID - 10.1007/978-1-59745-396-7_17 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2009;531:267-85. doi: 10.1007/978-1-59745-396-7_17.