PMID- 19348736
OWN - NLM
STAT- MEDLINE
DCOM- 20090727
LR  - 20161125
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 452
IP  - 3
DP  - 2009 Mar 20
TI  - Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the 
      expression of NMDA receptor NR1 subunit in morphine tolerant rats.
PG  - 268-72
LID - 10.1016/j.neulet.2009.01.073 [doi]
AB  - N-methyl-D-aspartate receptor (NMDAR) and Group I metabotropic glutamate 
      receptors (mGluRs) are involved in the process of morphine tolerance. Previous 
      studies have shown that Group I mGluRs can modulate NMDAR functions in the 
      central nervous system. The aim of the present study was to examine the influence 
      of Group I mGluRs antagonists on the expression of NMDA receptor NR1 subunit 
      (NR1) in the rat spinal cord. Morphine tolerance was induced in rats by repeated 
      administration of 10 microg morphine (intrathecal, i.t.) twice a day for 7 
      consecutive days. Tail flick test was used to assess the effect of Group I mGluRs 
      antagonist, AIDA ((RS)-1-Aminoindan-1,5 dicarboxylic acid) or mGluR5 antagonist, 
      MPEP (2-methyl-6-(phenylethynyl)pyridine) on morphine antinociceptive tolerance. 
      The expression of NR1 was measured by immunofluorescence and Western blot. 
      Behavioral tests revealed that both AIDA and MPEP attenuated the development of 
      morphine tolerance. The expression of NR1 was upregulated in the dorsal horn of 
      spinal cord after chronic morphine treatment. AIDA or MPEP co-administered with 
      morphine attenuated morphine induced upregulation of NR1. These findings suggest 
      that the development of morphine tolerance partly prevented by Group I mGluRs 
      antagonists may due to its inhibitory effect on the expression of NR1 subunit.
FAU - Liu, Jin-bian
AU  - Liu JB
AD  - Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated to 
      Shanghai Jiaotong University, Shanghai, China.
FAU - Yao, Yong-xing
AU  - Yao YX
FAU - Jiang, Wei
AU  - Jiang W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090204
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (1-aminoindan-1,5-dicarboxylic acid)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Grm5 protein, rat)
RN  - 0 (Indans)
RN  - 0 (NR1 NMDA receptor)
RN  - 0 (Pyridines)
RN  - 0 (Receptor, Metabotropic Glutamate 5)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (metabotropic glutamate receptor type 1)
RN  - 76I7G6D29C (Morphine)
RN  - 7VC0YVI27Y (6-methyl-2-(phenylethynyl)pyridine)
SB  - IM
MH  - Analgesics, Opioid/*administration & dosage
MH  - Animals
MH  - Drug Tolerance/*physiology
MH  - Excitatory Amino Acid Antagonists/administration & dosage
MH  - Indans/administration & dosage
MH  - Male
MH  - Morphine/*administration & dosage
MH  - Pain Threshold/drug effects
MH  - Posterior Horn Cells/drug effects/physiology
MH  - Pyridines/administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Metabotropic Glutamate 5
MH  - Receptors, Metabotropic Glutamate/*antagonists & inhibitors
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Spinal Cord/*drug effects/physiology
MH  - Up-Regulation/drug effects
EDAT- 2009/04/08 09:00
MHDA- 2009/07/28 09:00
CRDT- 2009/04/08 09:00
PHST- 2008/11/22 00:00 [received]
PHST- 2009/01/18 00:00 [revised]
PHST- 2009/01/29 00:00 [accepted]
PHST- 2009/04/08 09:00 [entrez]
PHST- 2009/04/08 09:00 [pubmed]
PHST- 2009/07/28 09:00 [medline]
AID - S0304-3940(09)00142-6 [pii]
AID - 10.1016/j.neulet.2009.01.073 [doi]
PST - ppublish
SO  - Neurosci Lett. 2009 Mar 20;452(3):268-72. doi: 10.1016/j.neulet.2009.01.073. Epub 
      2009 Feb 4.