PMID- 19350420
OWN - NLM
STAT- MEDLINE
DCOM- 20091001
LR  - 20211020
IS  - 1355-008X (Print)
IS  - 1355-008X (Linking)
VI  - 36
IP  - 1
DP  - 2009 Aug
TI  - Co-existence of glucagonoma with recurrent insulinoma in a patient with multiple 
      endocrine neoplasia-type 1 (MEN-1).
PG  - 20-4
LID - 10.1007/s12020-009-9183-1 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder 
      characterized by tumors of the parathyroid glands, the anterior pituitary, and 
      the endocrine pancreas. Our patient was a 58-year-old man who manifested typical 
      features of MEN-1 including primary hyperparathyroidism, lung carcinoid, and 
      lipomas and insulinoma. He was admitted to our hospital because of recurrent 
      hypoglycemia and a growth of pancreatic tumors. The first operation for 
      insulinoma was performed when he was 20 years old. We found a germline mutation 
      of the MEN1 gene (E45G, exon 2) in this patient. According to these examinations 
      and his clinical course, the patient was diagnosed as having a recurrence of 
      insulinoma. He subsequently underwent surgery for the pancreatic tumors. The 
      majority of these tumor cells were immunohistochemically positive for insulin and 
      negative for glucagon. A few nodules showed immunohistochemical staining 
      positivity for glucagon but they were negative for insulin. Although it is 
      uncommon for patients with MEN1 to exhibit insulinoma and glucagonoma, this case 
      suggests the need for careful analysis of pancreatic tumors in patients with 
      MEN1.
FAU - Nishiuchi, Takamasa
AU  - Nishiuchi T
AD  - Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1, 
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Imachi, Hitomi
AU  - Imachi H
FAU - Murao, Koji
AU  - Murao K
FAU - Fujiwara, Mako
AU  - Fujiwara M
FAU - Muraoka, Tomie
AU  - Muraoka T
FAU - Kikuchi, Fumi
AU  - Kikuchi F
FAU - Nishiuchi, Yukiko
AU  - Nishiuchi Y
FAU - Kushida, Yoshio
AU  - Kushida Y
FAU - Haba, Reiji
AU  - Haba R
FAU - Ishida, Toshihiko
AU  - Ishida T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090407
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Glucagonoma/genetics/*pathology
MH  - Humans
MH  - Insulinoma/genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*pathology
MH  - Neoplasm Recurrence, Local/genetics/pathology
MH  - Pancreatic Neoplasms/genetics/*pathology
MH  - Proto-Oncogene Proteins/genetics
EDAT- 2009/04/08 09:00
MHDA- 2009/10/02 06:00
CRDT- 2009/04/08 09:00
PHST- 2008/12/20 00:00 [received]
PHST- 2009/03/26 00:00 [accepted]
PHST- 2009/02/17 00:00 [revised]
PHST- 2009/04/08 09:00 [entrez]
PHST- 2009/04/08 09:00 [pubmed]
PHST- 2009/10/02 06:00 [medline]
AID - 10.1007/s12020-009-9183-1 [doi]
PST - ppublish
SO  - Endocrine. 2009 Aug;36(1):20-4. doi: 10.1007/s12020-009-9183-1. Epub 2009 Apr 7.