PMID- 19350645
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20211020
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 514
IP  - 5
DP  - 2009 Jun 10
TI  - Regulation of neonatal development of retinal ganglion cell dendrites by 
      neurotrophin-3 overexpression.
PG  - 449-58
LID - 10.1002/cne.22016 [doi]
AB  - The morphology of dendrites constrains and reflects the nature of synaptic inputs 
      to neurons. The visual system has served as a useful model to show how visual 
      function is determined by the arborization patterns of neuronal processes. In 
      retina, light ON and light OFF responding ganglion cells selectively elaborate 
      their dendritic arbors in distinct sublamina, where they receive, respectively, 
      inputs from ON and OFF bipolar cells. During neonatal maturation, the bilaminarly 
      distributed dendritic arbors of ON-OFF retinal ganglion cells (RGCs) are refined 
      to more narrowly localized monolaminar structures characteristic of ON or OFF 
      RGCs. Recently, brain-derived neurotrophic factor (BDNF) has been shown to 
      regulate this laminar refinement, and to enhance the development of dendritic 
      branches selectively of ON RGCs. Although other related neurotrophins are known 
      to regulate neuronal process formation in the central nervous system, little is 
      known about their action in maturing retina. Here, we report that overexpression 
      of neurotrophin-3 (NT-3) in the eye accelerates RGC laminar refinement before eye 
      opening. Furthermore, NT-3 overexpression increases dendritic branch number but 
      reduces dendritic elongation preferentially in ON-OFF RGCs, a process that also 
      occurs before eye opening. NT-3 overexpression does affect dendritic maturation 
      in ON RGCs, but to a much less degree. Taken together, our results suggest that 
      NT-3 and BDNF exhibit overlapping effects in laminar refinement but distinct 
      RGC-cell-type specific effects in shaping dendritic arborization during postnatal 
      development.
FAU - Liu, Xiaorong
AU  - Liu X
AD  - Department of Neurobiology and Physiology, Northwestern University, Evanston, 
      Illinois 60208, USA. cope@phy.ucsf.edu
FAU - Robinson, Michael L
AU  - Robinson ML
FAU - Schreiber, Ann Marie
AU  - Schreiber AM
FAU - Wu, Vincent
AU  - Wu V
FAU - Lavail, Matthew M
AU  - Lavail MM
FAU - Cang, Jianhua
AU  - Cang J
FAU - Copenhagen, David R
AU  - Copenhagen DR
LA  - eng
GR  - R01 EY018621/EY/NEI NIH HHS/United States
GR  - R01 EY012995/EY/NEI NIH HHS/United States
GR  - R01 EY001919-32/EY/NEI NIH HHS/United States
GR  - R01 EY019034-01/EY/NEI NIH HHS/United States
GR  - R01 EY019034/EY/NEI NIH HHS/United States
GR  - R01EY012995/EY/NEI NIH HHS/United States
GR  - R01 EY001919/EY/NEI NIH HHS/United States
GR  - R01EY018621/EY/NEI NIH HHS/United States
GR  - R01EY019034/EY/NEI NIH HHS/United States
GR  - P30 EY002162-32/EY/NEI NIH HHS/United States
GR  - R01 EY001869/EY/NEI NIH HHS/United States
GR  - R01EY001869/EY/NEI NIH HHS/United States
GR  - P30 EY002162/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dendrites/*physiology/ultrastructure
MH  - Eye/cytology/*growth & development/metabolism
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Transgenic
MH  - Microscopy, Confocal
MH  - Neurotrophin 3/genetics/*metabolism
MH  - Rats
MH  - Retinal Ganglion Cells/cytology/*physiology
PMC - PMC2691146
MID - NIHMS114256
EDAT- 2009/04/08 09:00
MHDA- 2009/05/30 09:00
PMCR- 2010/06/10
CRDT- 2009/04/08 09:00
PHST- 2009/04/08 09:00 [entrez]
PHST- 2009/04/08 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
PHST- 2010/06/10 00:00 [pmc-release]
AID - 10.1002/cne.22016 [doi]
PST - ppublish
SO  - J Comp Neurol. 2009 Jun 10;514(5):449-58. doi: 10.1002/cne.22016.