PMID- 19356078
OWN - NLM
STAT- MEDLINE
DCOM- 20090427
LR  - 20191111
IS  - 1874-0758 (Electronic)
IS  - 1872-3128 (Linking)
VI  - 2
IP  - 2
DP  - 2008 Apr
TI  - The effects of the 3,4-methylenedioxymethamphetamine (Ecstasy) in some cerebral 
      areas: role of the oxidative stress.
PG  - 95-9
AB  - The purpose of the present review is to examine the effect of the acute 
      administration (20 mg/ Kg, i.p.) of the 3,4 methylenedioxymethamphetamine (MDMA) 
      in different cerebral areas of rats to better understand the mechanism underlying 
      the toxicity induced by cellular oxidative stress. For this purpose the 
      biochemical parameters of the antioxidant non-enzymatic cellular defense system 
      have been studied (the reduced Glutathione (GSH), the Glutathione Disulfide 
      (GSSG), the Ascorbic Acid (AA) and malondialdehyde (MDA) which indicates 
      perioxidative damage) in the hippocampus, striate, frontal cortex both in treated 
      animals and in control groups to realize a qualitative-quantitative evaluation of 
      the possible alterations of the neuronal redox state induced by the 
      administration of Ecstasy. The administration of MDMA induced the following 
      variations of the antioxidant non enzymatic defense system: 1. the levels of the 
      AA in the treated animals compared with the control group were increased in the 
      striate, hippocampus and in the frontal cortex both at 3h and 6h. 2. In the 
      striate, also MDA was significantly increased both after 3 h and 6 h, while in 
      the hippocampus and in the frontal cortex the MDA was significantly increased 
      after 6 h. 3. An increase of GSH was also observed after 3 h and 6 h in the 
      hippocampus and in the striate while no significative variation were observed in 
      the frontal cortex of the treated rats. 4. An increase of GSSG was significative 
      in the hippocampus and striate at 3h, while at 6h it was significative only in 
      the striate. In conclusion the results of our study seem to confirm the role of 
      the oxidative stress in the mechanism of neuronal toxicity induced by Ecstasy and 
      leads us to hypothesize a possible role of the antioxidant substances in the 
      therapeutic treatment of the intoxicants by MDMA.
FAU - Franzese, Sergio
AU  - Franzese S
AD  - Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don 
      Melillo, Fisciano, Salerno, Italia.
FAU - Capasso, Anna
AU  - Capasso A
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Drug Metab Lett
JT  - Drug metabolism letters
JID - 101313587
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Frontal Lobe/drug effects/metabolism
MH  - Hallucinogens/*toxicity
MH  - Hippocampus/drug effects/metabolism
MH  - Injections, Intraperitoneal
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurons/drug effects/metabolism
MH  - Oxidation-Reduction/drug effects
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
MH  - Visual Cortex/drug effects/metabolism
EDAT- 2009/04/10 09:00
MHDA- 2009/04/28 09:00
CRDT- 2009/04/10 09:00
PHST- 2009/04/10 09:00 [entrez]
PHST- 2009/04/10 09:00 [pubmed]
PHST- 2009/04/28 09:00 [medline]
AID - 10.2174/187231208784040924 [doi]
PST - ppublish
SO  - Drug Metab Lett. 2008 Apr;2(2):95-9. doi: 10.2174/187231208784040924.