PMID- 19356870
OWN - NLM
STAT- MEDLINE
DCOM- 20090723
LR  - 20131121
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 187
IP  - 1-3
DP  - 2009 May 30
TI  - Optimization of HS-SPME/GC-MS analysis and its use in the profiling of illicit 
      ecstasy tablets (Part 1).
PG  - 73-80
LID - 10.1016/j.forsciint.2009.03.004 [doi]
AB  - A headspace solid-phase microextraction procedure (HS-SPME) was developed for the 
      profiling of traces present in 3,4-methylenedioxymethylampethamine (MDMA). Traces 
      were first extracted using HS-SPME and then analyzed by gas chromatography-mass 
      spectroscopy (GC-MS). The HS-SPME conditions were optimized using varying 
      conditions. Optimal results were obtained when 40 mg of crushed MDMA sample was 
      heated at 80 degrees C for 15 min, followed by extraction at 80 degrees C for 15 
      min with a polydimethylsiloxane/divinylbenzene coated fibre. A total of 31 
      compounds were identified as traces related to MDMA synthesis, namely precursors, 
      intermediates or by-products. In addition some fatty acids used as tabletting 
      materials and caffeine used as adulterant, were also detected. The use of a 
      restricted set of 10 target compounds was also proposed for developing a 
      screening tool for clustering samples having close profile. 114 seizures were 
      analyzed using an SPME auto-sampler (MultiPurpose Samples MPS2), purchased from 
      Gerstel GMBH & Co. (Germany), and coupled to GC-MS. The data was handled using 
      various pre-treatment methods, followed by the study of similarities between 
      sample pairs based on the Pearson correlation. The results show that HS-SPME, 
      coupled with the suitable statistical method is a powerful tool for 
      distinguishing specimens coming from the same seizure and specimens coming from 
      different seizures. This information can be used by law enforcement personnel to 
      visualize the ecstasy distribution network as well as the clandestine tablet 
      manufacturing.
FAU - Bonadio, Federica
AU  - Bonadio F
AD  - Ecole des Sciences Criminelles, Institut de Police Scientifique, University of 
      Lausanne, Batochime, CH-1015, Lausanne-Dorigny, Switzerland.
FAU - Margot, Pierre
AU  - Margot P
FAU - Delemont, Olivier
AU  - Delemont O
FAU - Esseiva, Pierre
AU  - Esseiva P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090407
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Tablets)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Area Under Curve
MH  - Chemical Fractionation/methods
MH  - Drug Contamination
MH  - False Positive Reactions
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Models, Chemical
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Tablets/*analysis
EDAT- 2009/04/10 09:00
MHDA- 2009/07/25 09:00
CRDT- 2009/04/10 09:00
PHST- 2008/09/14 00:00 [received]
PHST- 2009/01/09 00:00 [revised]
PHST- 2009/03/02 00:00 [accepted]
PHST- 2009/04/10 09:00 [entrez]
PHST- 2009/04/10 09:00 [pubmed]
PHST- 2009/07/25 09:00 [medline]
AID - S0379-0738(09)00095-4 [pii]
AID - 10.1016/j.forsciint.2009.03.004 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2009 May 30;187(1-3):73-80. doi: 
      10.1016/j.forsciint.2009.03.004. Epub 2009 Apr 7.