PMID- 19357026
OWN - NLM
STAT- MEDLINE
DCOM- 20090630
LR  - 20090409
IS  - 1499-3872 (Print)
VI  - 8
IP  - 2
DP  - 2009 Apr
TI  - Detection of human leukocyte antigen compatibility and antibodies in liver 
      transplantation in China.
PG  - 141-5
AB  - BACKGROUND: The exact roles of human leukocyte antigen (HLA) compatibility, HLA 
      antibodies and underlying diseases in acute rejection of liver transplants are 
      not clear. Moreover, cytomegalovirus (CMV) infection, one of the most common 
      infections after transplantation, is related to HLA genotype and the incidence of 
      acute rejection. METHODS: Since there are controversial reports, we analyzed the 
      impact of HLA matching, HLA antibodies and underlying diseases in 38 liver 
      transplant recipients in China, and assessed the association of CMV infection and 
      HLA compatibility. RESULTS: The frequency of no HLA compatibility was high in 
      patients without antigenemia (P=0.019). All 17 patients with HLA-A matching 
      developed antigenemia (P<0.05). Patients with three HLA locus matches were not 
      found in patients with acute rejection (P<0.05), and no relationship between HLA 
      antibodies and acute rejection was found (P>0.05). In patients with acute 
      rejection, no differences were found in the incidence of acute rejection in 
      transplants for hepatitis B, tumors, or combined hepatitis B and tumors (P>0.05). 
      CONCLUSIONS: There are fewer acute rejections in transplants with more HLA 
      compatibilities. Specific investigations of underlying diseases and HLA typing 
      may be necessary in liver transplantation. The mechanisms of CMV infection and 
      HLA matching should be further studied. HLA before transplantation should be 
      examined for the prevention of acute rejection and CMV infection.
FAU - Meng, Xue-Qin
AU  - Meng XQ
AD  - Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public 
      Health, First Affiliated Hospital, Zhejiang University School of Medicine, 
      Hangzhou 310003, China.
FAU - Zhang, Xuan
AU  - Zhang X
FAU - Fan, Jun
AU  - Fan J
FAU - Zhou, Lin
AU  - Zhou L
FAU - Hao, Bing
AU  - Hao B
FAU - Chen, Xiao-Ming
AU  - Chen XM
FAU - Ma, Wei-Hang
AU  - Ma WH
FAU - Zheng, Shu-Sen
AU  - Zheng SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Hepatobiliary Pancreat Dis Int
JT  - Hepatobiliary & pancreatic diseases international : HBPD INT
JID - 101151457
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus Infections/etiology
MH  - Female
MH  - Graft Rejection/etiology
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/*blood
MH  - *Liver Transplantation/adverse effects/immunology
MH  - Male
MH  - Middle Aged
EDAT- 2009/04/10 09:00
MHDA- 2009/07/01 09:00
CRDT- 2009/04/10 09:00
PHST- 2009/04/10 09:00 [entrez]
PHST- 2009/04/10 09:00 [pubmed]
PHST- 2009/07/01 09:00 [medline]
AID - 1211 [pii]
PST - ppublish
SO  - Hepatobiliary Pancreat Dis Int. 2009 Apr;8(2):141-5.