PMID- 19358255 OWN - NLM STAT- MEDLINE DCOM- 20090611 LR - 20090526 IS - 1531-4995 (Electronic) IS - 0023-852X (Linking) VI - 119 IP - 6 DP - 2009 Jun TI - IgE-mediated fungal allergy in allergic fungal sinusitis. PG - 1046-52 LID - 10.1002/lary.20170 [doi] AB - This review will address the current knowledge of the pathogenic mechanisms in allergic fungal sinusitis (AFS) and the basis for the current classification of a subgroup of chronic rhinosinusitis patients. Special attention is directed to the role of immunoglobulin E (IgE)-mediated fungal allergy in the pathogenesis of AFS. Concepts relating to the mucosal inflammatory response are introduced, as a knowledge of the reactions of the sinus mucosal cells can lead to a better understanding of the mechanisms perpetuating and maintaining the chronic inflammation. Laryngoscope, 2009. FAU - Pant, Harshita AU - Pant H AD - Department of Otorhinolaryngology Head and Neck Surgery, the University of Adelaide, Adelaide, Australia. panth@upmc.edu FAU - Schembri, Mark A AU - Schembri MA FAU - Wormald, Peter J AU - Wormald PJ FAU - Macardle, Peter J AU - Macardle PJ LA - eng PT - Journal Article PT - Review PL - United States TA - Laryngoscope JT - The Laryngoscope JID - 8607378 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Chronic Disease MH - Eosinophilia/diagnosis/*immunology MH - Fungi/*immunology MH - Humans MH - Hypersensitivity, Immediate/diagnosis/immunology MH - Immunoglobulin E/*blood MH - Mucous Membrane/immunology MH - Rhinitis, Allergic, Perennial/diagnosis/*immunology MH - Sinusitis/diagnosis/*immunology RF - 79 EDAT- 2009/04/10 09:00 MHDA- 2009/06/12 09:00 CRDT- 2009/04/10 09:00 PHST- 2009/04/10 09:00 [entrez] PHST- 2009/04/10 09:00 [pubmed] PHST- 2009/06/12 09:00 [medline] AID - 10.1002/lary.20170 [doi] PST - ppublish SO - Laryngoscope. 2009 Jun;119(6):1046-52. doi: 10.1002/lary.20170.