PMID- 19358879 OWN - NLM STAT- MEDLINE DCOM- 20100111 LR - 20240312 IS - 1873-7544 (Electronic) IS - 0306-4522 (Print) IS - 0306-4522 (Linking) VI - 164 IP - 1 DP - 2009 Nov 24 TI - Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. PG - 108-20 LID - 10.1016/j.neuroscience.2009.03.081 [doi] AB - There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans. FAU - Casey, B J AU - Casey BJ AD - Weill Cornell Medical College, New York, NY 10065, USA. bjc2002@med.cornell.edu FAU - Glatt, C E AU - Glatt CE FAU - Tottenham, N AU - Tottenham N FAU - Soliman, F AU - Soliman F FAU - Bath, K AU - Bath K FAU - Amso, D AU - Amso D FAU - Altemus, M AU - Altemus M FAU - Pattwell, S AU - Pattwell S FAU - Jones, R AU - Jones R FAU - Levita, L AU - Levita L FAU - McEwen, B AU - McEwen B FAU - Magarinos, A M AU - Magarinos AM FAU - Gunnar, M AU - Gunnar M FAU - Thomas, K M AU - Thomas KM FAU - Mezey, J AU - Mezey J FAU - Clark, A G AU - Clark AG FAU - Hempstead, B L AU - Hempstead BL FAU - Lee, F S AU - Lee FS LA - eng GR - R01 MH73175/MH/NIMH NIH HHS/United States GR - R01 NS052819/NS/NINDS NIH HHS/United States GR - P50 MH079513-01A1/MH/NIMH NIH HHS/United States GR - R01 MH073175/MH/NIMH NIH HHS/United States GR - R01 MH073175-01A1/MH/NIMH NIH HHS/United States GR - T32 GM007739/GM/NIGMS NIH HHS/United States GR - P50 MH079513/MH/NIMH NIH HHS/United States GR - R01 MH091864/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20090407 PL - United States TA - Neuroscience JT - Neuroscience JID - 7605074 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Aging/*genetics MH - Animals MH - Brain/growth & development/metabolism MH - Brain-Derived Neurotrophic Factor/*genetics/metabolism MH - *Environment MH - Human Development MH - Humans MH - Mice MH - *Models, Genetic MH - Phenotype MH - Polymorphism, Genetic PMC - PMC2760671 MID - NIHMS108144 EDAT- 2009/04/11 09:00 MHDA- 2010/01/12 06:00 PMCR- 2010/11/24 CRDT- 2009/04/11 09:00 PHST- 2009/01/26 00:00 [received] PHST- 2009/03/23 00:00 [revised] PHST- 2009/03/30 00:00 [accepted] PHST- 2009/04/11 09:00 [entrez] PHST- 2009/04/11 09:00 [pubmed] PHST- 2010/01/12 06:00 [medline] PHST- 2010/11/24 00:00 [pmc-release] AID - S0306-4522(09)00577-6 [pii] AID - 10.1016/j.neuroscience.2009.03.081 [doi] PST - ppublish SO - Neuroscience. 2009 Nov 24;164(1):108-20. doi: 10.1016/j.neuroscience.2009.03.081. Epub 2009 Apr 7.