PMID- 19358977 OWN - NLM STAT- MEDLINE DCOM- 20090831 LR - 20220309 IS - 1873-2402 (Electronic) IS - 0006-3223 (Print) IS - 0006-3223 (Linking) VI - 66 IP - 1 DP - 2009 Jul 1 TI - Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. PG - 84-90 LID - 10.1016/j.biopsych.2009.02.007 [doi] AB - BACKGROUND: Major depressive disorder is a leading debilitating disease known to occur at a two-fold higher rate in women than in men. The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking. METHODS: Using the chronic unpredictable stress (CUS) paradigm, we investigated whether male and female mice with inducible BDNF deletion in the forebrain were more susceptible to depression-related behavior. RESULTS: We demonstrate that in certain behavioral measures the loss of BDNF lowers the threshold for female mice studied at random throughout estrus to display anxiogenic and anhedonic behaviors after chronic stress compared with wild-type female mice. However, the loss of BDNF in forebrain does not increase the susceptibility to depression-like behavior in male mice. CONCLUSIONS: These gender differences suggest a role for BDNF in mediating some aspects of depression-related behavior in females. FAU - Autry, Anita E AU - Autry AE AD - Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA. FAU - Adachi, Megumi AU - Adachi M FAU - Cheng, Pengfei AU - Cheng P FAU - Monteggia, Lisa M AU - Monteggia LM LA - eng GR - T32 DA007290/DA/NIDA NIH HHS/United States GR - R01 MH070727/MH/NIMH NIH HHS/United States GR - T32 DA07290/DA/NIDA NIH HHS/United States GR - MH070727/MH/NIMH NIH HHS/United States GR - R01 MH070727-04/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20090409 PL - United States TA - Biol Psychiatry JT - Biological psychiatry JID - 0213264 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (RNA, Messenger) RN - 57-50-1 (Sucrose) RN - W980KJ009P (Corticosterone) SB - IM MH - Analysis of Variance MH - Animals MH - Body Weight/physiology MH - Brain-Derived Neurotrophic Factor/genetics/*metabolism MH - Corticosterone/metabolism MH - Depression/*etiology MH - Disease Models, Animal MH - Exploratory Behavior/physiology MH - Female MH - Food Preferences MH - Hindlimb Suspension/methods MH - Male MH - Mice MH - Motor Activity/physiology MH - RNA, Messenger/metabolism MH - Sex Factors MH - Signal Transduction/*physiology MH - Stress, Psychological/*complications MH - Sucrose/metabolism PMC - PMC2734472 MID - NIHMS128069 EDAT- 2009/04/11 09:00 MHDA- 2009/09/01 06:00 PMCR- 2010/07/01 CRDT- 2009/04/11 09:00 PHST- 2008/08/10 00:00 [received] PHST- 2009/01/30 00:00 [revised] PHST- 2009/02/03 00:00 [accepted] PHST- 2009/04/11 09:00 [entrez] PHST- 2009/04/11 09:00 [pubmed] PHST- 2009/09/01 06:00 [medline] PHST- 2010/07/01 00:00 [pmc-release] AID - S0006-3223(09)00192-9 [pii] AID - 10.1016/j.biopsych.2009.02.007 [doi] PST - ppublish SO - Biol Psychiatry. 2009 Jul 1;66(1):84-90. doi: 10.1016/j.biopsych.2009.02.007. Epub 2009 Apr 9.