PMID- 19359449 OWN - NLM STAT- MEDLINE DCOM- 20090811 LR - 20090410 IS - 1545-7222 (Electronic) IS - 0895-0172 (Linking) VI - 21 IP - 1 DP - 2009 Winter TI - Brain-derived neurotrophic factor Val66Met polymorphism: association with psychopathological symptoms of schizophrenia? PG - 30-7 AB - Brain-derived neurotrophic factor (BDNF) has been proposed as a risk factor for schizophrenia, but no consistent association between BDNF Val66Met polymorphism and schizophrenia has been established. Therefore, analyses with larger sample sizes and better methodology are needed. To examine whether BDNF Val66Met polymorphism is associated with schizophrenia, schizophrenia patients (n=251) and healthy volunteers (n=284) were recruited for a case-control analysis. Pretreatment psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) in a subset of 125 hospitalized schizophrenia patients who were drug-free or drug-naive. Genotyping was performed using polymerase chain reaction, restriction fragment length polymorphism (RFLP), and direct screening techniques. With the exception of nominally significant associations between BDNF Val66Met variation and PANSS total, negative, or general scores, no association between the BDNF Val66Met polymorphism and schizophrenia was found. However, this polymorphism may reduce psychopathology, in particular negative symptoms, in schizophrenia. FAU - Chang, Hsin-An AU - Chang HA AD - Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan, ROC. FAU - Lu, Ru-Band AU - Lu RB FAU - Shy, Mee-Jen AU - Shy MJ FAU - Chang, Chuan-Chia AU - Chang CC FAU - Lee, Meei-Shyuan AU - Lee MS FAU - Huang, San-Yuan AU - Huang SY LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Neuropsychiatry Clin Neurosci JT - The Journal of neuropsychiatry and clinical neurosciences JID - 8911344 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Analysis of Variance MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Female MH - Gene Frequency MH - Humans MH - Logistic Models MH - Male MH - Middle Aged MH - *Mutation, Missense MH - Phenotype MH - Polymerase Chain Reaction MH - *Polymorphism, Genetic MH - Polymorphism, Restriction Fragment Length MH - Schizophrenia/*genetics MH - *Schizophrenic Psychology MH - Sequence Analysis, DNA MH - Severity of Illness Index EDAT- 2009/04/11 09:00 MHDA- 2009/08/12 09:00 CRDT- 2009/04/11 09:00 PHST- 2009/04/11 09:00 [entrez] PHST- 2009/04/11 09:00 [pubmed] PHST- 2009/08/12 09:00 [medline] AID - 21/1/30 [pii] AID - 10.1176/jnp.2009.21.1.30 [doi] PST - ppublish SO - J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):30-7. doi: 10.1176/jnp.2009.21.1.30.