PMID- 19359612
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20181201
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 106
IP  - 6
DP  - 2009 Jun
TI  - Involvement of central angiotensin II type 1 receptors in LPS-induced systemic 
      vasopressin release and blood pressure regulation in rats.
PG  - 1943-8
LID - 10.1152/japplphysiol.90516.2008 [doi]
AB  - The purpose of this study was to evaluate the involvement of central angiotensin 
      II (ANG II) and ANG II type 1 (AT(1)) receptors in systemic release of arginine 
      vasopressin (AVP) and blood pressure regulation during endotoxemia. LPS (150 
      microg/kg) was injected intravenously 30 min after intracerebroventricular (icv) 
      losartan (50 microg), an AT(1) receptor antagonist, or subcutaneous (sc) 
      captopril (50 mg/kg), an angiotensin-converting enzyme inhibitor. Rats with icv 
      and sc saline injections served as control. LPS administration increased plasma 
      AVP concentration from 2.1 +/- 0.2 to 15.2 +/- 2.5 pg/ml (60 min after LPS 
      injection) without significant changes in plasma osmolality or hematocrit. 
      LPS-induced AVP secretion was significantly attenuated by pretreatment with icv 
      losartan (2.3 +/- 0.5 to 3.7 +/- 0.5 pg/ml) but was not attenuated after 
      peripheral captopril treatment (2.2 +/- 0.6 to 17.6 +/- 4.2 pg/ml). LPS 
      administration significantly decreased systolic blood pressure (SBP) by 22.7 +/- 
      5.4 mmHg after intravenous LPS injection in icv losartan-treated rats, while SBP 
      remained unchanged in vehicle-treated or sc captopril-treated rats by intravenous 
      LPS. These results indicate that central AT(1) receptors, not responsive to 
      peripheral ANG II, play an important role in systemic AVP secretion and 
      maintenance of blood pressure during endotoxemia.
FAU - Shimizu, Fumihiro
AU  - Shimizu F
AD  - Department of Environmental Health, Nara Women's Univesity, Kitauoya Nishimachi, 
      Nara 630-8506, Japan.
FAU - Kasai, Toshihiro
AU  - Kasai T
FAU - Takamata, Akira
AU  - Takamata A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090409
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Angiotensin II Type 2 Receptor Blockers)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Receptor, Angiotensin, Type 2)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 9G64RSX1XD (Captopril)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/pharmacology
MH  - Angiotensin II Type 2 Receptor Blockers
MH  - Angiotensin-Converting Enzyme Inhibitors/pharmacology
MH  - Animals
MH  - Arginine Vasopressin/blood/metabolism
MH  - Blood Pressure/drug effects
MH  - Captopril/administration & dosage/pharmacology
MH  - Disease Models, Animal
MH  - Drug Therapy, Combination
MH  - Endotoxemia/*metabolism/physiopathology
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Lipopolysaccharides
MH  - Losartan/administration & dosage/pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Angiotensin, Type 1/*metabolism
MH  - Receptor, Angiotensin, Type 2/*metabolism
EDAT- 2009/04/11 09:00
MHDA- 2009/07/08 09:00
CRDT- 2009/04/11 09:00
PHST- 2009/04/11 09:00 [entrez]
PHST- 2009/04/11 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
AID - 90516.2008 [pii]
AID - 10.1152/japplphysiol.90516.2008 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2009 Jun;106(6):1943-8. doi: 
      10.1152/japplphysiol.90516.2008. Epub 2009 Apr 9.