PMID- 19359792
OWN - NLM
STAT- MEDLINE
DCOM- 20090608
LR  - 20190827
IS  - 1348-2246 (Electronic)
IS  - 0910-6340 (Linking)
VI  - 25
IP  - 4
DP  - 2009 Apr
TI  - Ecstasy analysis by monolithic materials-capillary electrochromatography.
PG  - 517-22
AB  - Monolithic columns were successfully prepared and used with capillary 
      electrochromatography for the analysis of 3,4-methylenedioxymethamphetamine 
      (MDMA) in ecstasy tablets and its metabolites in urine samples. Cationic and 
      neutral monolith columns provided better efficiencies than anionic monoliths. The 
      neutral butyl methacrylate (BMA) monolith column provided symmetrical peaks with 
      the highest efficiency, high resolution and short analysis times. The developed 
      method using BMA monolithic column provided the detection limits for MDMA and its 
      metabolites at 1 microg mL(-1) with excellent intra-day and inter-day precision 
      and linearity from 7.5 to 100 microg mL(-1) (R(2) > or = 0.99). MDMA was found as 
      the main component in ecstasy tablets while 4-hydroxy-3-methoxymethamphetamine as 
      the major metabolite in urine samples. High recoveries (97% for MDMA from tablets 
      and 84-102% for its metabolites from urine samples) were obtained using simple 
      ultrasonic extraction for ecstasy tablets and liquid-liquid extraction for urine 
      samples.
FAU - Choodum, Aree
AU  - Choodum A
AD  - Trace Analysis and Biosensor Research Center, Department of Chemistry, Prince of 
      Songkla University, Hat Yai, Songkhla 90112, Thailand.
FAU - Thavarungkul, Panote
AU  - Thavarungkul P
FAU - Kanatharana, Proespichaya
AU  - Kanatharana P
FAU - Smith, Norman W
AU  - Smith NW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Anal Sci
JT  - Analytical sciences : the international journal of the Japan Society for 
      Analytical Chemistry
JID - 8511078
RN  - 0 (Tablets)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analysis/isolation & purification/metabolism/urine
MH  - Capillary Electrochromatography
MH  - Electroosmosis
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Microscopy, Electron, Scanning
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/isolation & 
      purification/metabolism/urine
MH  - Osmolar Concentration
MH  - Reproducibility of Results
MH  - Tablets
MH  - Time Factors
EDAT- 2009/04/11 09:00
MHDA- 2009/06/09 09:00
CRDT- 2009/04/11 09:00
PHST- 2009/04/11 09:00 [entrez]
PHST- 2009/04/11 09:00 [pubmed]
PHST- 2009/06/09 09:00 [medline]
AID - JST.JSTAGE/analsci/25.517 [pii]
AID - 10.2116/analsci.25.517 [doi]
PST - ppublish
SO  - Anal Sci. 2009 Apr;25(4):517-22. doi: 10.2116/analsci.25.517.