PMID- 19360113
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120925
LR  - 20211020
IS  - 1687-4757 (Print)
IS  - 1687-4765 (Electronic)
VI  - 2009
DP  - 2009
TI  - The role of the PGC1alpha Gly482Ser polymorphism in weight gain due to intensive 
      diabetes therapy.
PG  - 649286
LID - 10.1155/2009/649286 [doi]
LID - 649286
AB  - The Diabetes Control and Complications Trial (DCCT) involved intensive diabetes 
      therapy of subjects with type 1 diabetes mellitus (T1DM) for an average period of 
      6.5 years. A subset of these subjects gained excessive weight. We tested for 
      association of polymorphisms in 8 candidate genes with the above trait. We found 
      the Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma 
      coactivator-1alpha (PGC1alpha) to be significantly associated with weight gain in males 
      (P = .0045) but not in females. The Ser allele was associated with greater weight 
      gain than the Gly allele (P = .005). Subjects with a family history of type 2 
      diabetes mellitus (T2DM) were more common among those who gained excessive 
      weight. We conclude that T2DM and the Gly482Ser polymorphism in PGC1alpha contribute 
      to the effect of intensive diabetes therapy on weight gain in males with T1DM.
FAU - Deeb, Samir S
AU  - Deeb SS
AD  - Division of Medical Genetics, Department of Medicine, University of Washington, 
      Seattle, WA 98195-7720, USA. sdeeb@u.washington.edu
FAU - Brunzell, John D
AU  - Brunzell JD
LA  - eng
GR  - P01 DK002456/DK/NIDDK NIH HHS/United States
GR  - P30 DK017047/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20090407
PL  - United States
TA  - PPAR Res
JT  - PPAR research
JID - 101269101
PMC - PMC2666270
EDAT- 2009/04/11 09:00
MHDA- 2009/04/11 09:01
PMCR- 2009/04/07
CRDT- 2009/04/11 09:00
PHST- 2008/12/13 00:00 [received]
PHST- 2009/01/14 00:00 [accepted]
PHST- 2009/04/11 09:00 [entrez]
PHST- 2009/04/11 09:00 [pubmed]
PHST- 2009/04/11 09:01 [medline]
PHST- 2009/04/07 00:00 [pmc-release]
AID - 10.1155/2009/649286 [doi]
PST - ppublish
SO  - PPAR Res. 2009;2009:649286. doi: 10.1155/2009/649286. Epub 2009 Apr 7.