PMID- 19360749
OWN - NLM
STAT- MEDLINE
DCOM- 20091027
LR  - 20220317
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 31
IP  - 9
DP  - 2009 Sep
TI  - Endoscopic horizontal partial laryngectomy by CO(2) laser in the management of 
      supraglottic squamous cell carcinoma.
PG  - 1196-206
LID - 10.1002/hed.21085 [doi]
AB  - BACKGROUND: The objective of this study was to evaluate the results of endoscopic 
      horizontal supraglottic laryngectomy (EHSL) by CO(2) laser. METHODS: Between 1996 
      and 2005, 78 patients underwent a horizontal supraglottic laryngectomy operation 
      (HSL) with an external approach and 70 underwent laser EHSL, as treatment for 
      supraglottic laryngeal squamous cell carcinoma (LSCC). We evaluated oncological 
      endpoints, comparing the external and the endoscopic approach. RESULTS: Among 
      patients primarily treated by EHSL, the 5-year disease-specific survival (DSS) 
      was 89% (vs 80% in the external approach group). Statistical analysis did not 
      reveal significant differences between the 2 groups as for survival nor for organ 
      preservation. The most significant clinical predictor for DSS is neck relapse (p 
      < .0001). CONCLUSIONS: This study confirms the effectiveness of laser EHSL in 
      which oncological outcome is similar to the external approach and functional 
      results are probably better. Neck management in this setting is fundamental to 
      warrant the best survival.
FAU - Bussu, Francesco
AU  - Bussu F
AD  - Institute of Otorhinolaryngology, Universita Cattolica del Sacro Cuore, Rome, 
      Italy. busfranc@libero.it
FAU - Almadori, Giovanni
AU  - Almadori G
FAU - De Corso, Eugenio
AU  - De Corso E
FAU - Rizzo, Davide
AU  - Rizzo D
FAU - Rigante, Mario
AU  - Rigante M
FAU - Parrilla, Claudio
AU  - Parrilla C
FAU - Valentini, Vincenzo
AU  - Valentini V
FAU - Paludetti, Gaetano
AU  - Paludetti G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/pathology/*surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/pathology/*surgery
MH  - Laryngectomy/*methods
MH  - *Laryngoscopy
MH  - *Laser Therapy
MH  - *Lasers, Gas
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications
EDAT- 2009/04/11 09:00
MHDA- 2009/10/29 06:00
CRDT- 2009/04/11 09:00
PHST- 2009/04/11 09:00 [entrez]
PHST- 2009/04/11 09:00 [pubmed]
PHST- 2009/10/29 06:00 [medline]
AID - 10.1002/hed.21085 [doi]
PST - ppublish
SO  - Head Neck. 2009 Sep;31(9):1196-206. doi: 10.1002/hed.21085.