PMID- 19361458
OWN - NLM
STAT- MEDLINE
DCOM- 20090706
LR  - 20221207
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 403
IP  - 1-2
DP  - 2009 May
TI  - Circulating concentrations of monocyte chemoattractant protein-1 are associated 
      with menopause status in Korean women.
PG  - 92-6
LID - 10.1016/j.cca.2009.01.025 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays a role in adipose 
      tissue inflammation and insulin resistance. Human circulating MCP-1 
      concentrations reportedly increase or remain unchanged according to obesity or 
      insulin resistance in various ethnic populations; whether or not circulating 
      MCP-1 concentrations increase after menopause has remained unclear. METHODS: We 
      investigated the relationship between circulating MCP-1 concentrations and 
      obesity or insulin resistance, and the relationship between circulating MCP-1 and 
      menopause status in premenopausal (n=111) and postmenopausal (n=64) Korean women. 
      RESULTS: Circulating MCP-1 concentrations were significantly higher in 
      postmenopausal women than in obesity-matched premenopausal women; they did not 
      differ between non-obese and obese subgroups of pre- and postmenopausal women. 
      Circulating MCP-1 concentrations had a relationship with menopause status 
      (rho=0.500, p=0.000), irrespective of obesity, but no relationship with obesity 
      or insulin resistance. Circulating MCP-1 concentrations correlated with serum 
      triglycerides (r=0.4, p=0.001) and also correlated with serum triglyceride 
      concentrations, after adjusting for age and obesity, in postmenopausal women. 
      CONCLUSIONS: Circulating MCP-1 concentrations are associated with menopause 
      status itself, irrespective of obesity; they do not correlate with obesity or 
      insulin resistance in Korean women, most of whom are not severely obese.
FAU - Park, Kang-Seo
AU  - Park KS
AD  - Department of Internal Medicine, School of Medicine, Eulji University, Daejeon, 
      Korea.
FAU - Ahn, Kyu-Jeung
AU  - Ahn KJ
FAU - Kim, Byung-Joon
AU  - Kim BJ
FAU - Kim, Hyun-Jin
AU  - Kim HJ
FAU - Yoo, Seung Min
AU  - Yoo SM
FAU - Kim, Ju-Young
AU  - Kim JY
FAU - Lee, Ki-Ho
AU  - Lee KH
FAU - Baik, Haing-Woon
AU  - Baik HW
FAU - Lee, Seong-Kyu
AU  - Lee SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090204
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - *Asian People
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Korea
MH  - Menopause/*blood
MH  - Middle Aged
MH  - Obesity/blood
MH  - Postmenopause/blood
MH  - Premenopause/blood
EDAT- 2009/04/14 09:00
MHDA- 2009/07/07 09:00
CRDT- 2009/04/14 09:00
PHST- 2008/11/03 00:00 [received]
PHST- 2009/01/25 00:00 [revised]
PHST- 2009/01/26 00:00 [accepted]
PHST- 2009/04/14 09:00 [entrez]
PHST- 2009/04/14 09:00 [pubmed]
PHST- 2009/07/07 09:00 [medline]
AID - S0009-8981(09)00067-9 [pii]
AID - 10.1016/j.cca.2009.01.025 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2009 May;403(1-2):92-6. doi: 10.1016/j.cca.2009.01.025. Epub 2009 
      Feb 4.