PMID- 19363274
OWN - NLM
STAT- MEDLINE
DCOM- 20091216
LR  - 20220408
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 17
IP  - 2
DP  - 2009
TI  - Brain-derived neurotrophic factor levels in Alzheimer's disease.
PG  - 337-41
LID - 10.3233/JAD-2009-1051 [doi]
AB  - The current search for biomarkers that are diagnostic and/or prognostic of 
      Alzheimer's disease (AD) is of vital importance given the rapidly aging 
      population. It was recently reported that brain-derived neurotrophic factor 
      (BDNF) fluctuated according to AD severity, suggesting that BDNF might have 
      utility for diagnostics and monitoring of therapeutic efficacy. The current study 
      sought to examine whether BDNF levels varied according to AD severity, as 
      previously reported. There were 196 participants (Probable AD, n = 98; Controls, 
      n = 98) in the Texas Alzheimer's Research Consortium (TARC) Longitudinal Research 
      Cohort available for analysis. BDNF levels were assayed via multiplex 
      immunoassay. Regression analyses were utilized to examine the relation between 
      BDNF levels, Mini-Mental Status Examination, and Clinical Dementia Rating scores 
      adjusting for age and gender. In adjusted models, BDNF levels did not distinguish 
      between AD patients and normal controls and did not significantly predict AD 
      severity or global cognitive functioning. In conclusion, these findings do not 
      support the notion that BDNF serves as a diagnostic marker for AD or disease 
      severity. It is likely that the most accurate approach to identifying biomarkers 
      of AD will be through an algorithmic approach that combines multiple markers 
      reflective of various pathways.
FAU - O'Bryant, Sid E
AU  - O'Bryant SE
AD  - Texas Tech University Health Science Center, Department of Neurology, 3601 4th 
      St. STOP 8321, Lubbock, TX 79430, USA. sid.obryant@ttuhsc.edu
FAU - Hobson, Valerie
AU  - Hobson V
FAU - Hall, James R
AU  - Hall JR
FAU - Waring, Stephen C
AU  - Waring SC
FAU - Chan, Wenyan
AU  - Chan W
FAU - Massman, Paul
AU  - Massman P
FAU - Lacritz, Laura
AU  - Lacritz L
FAU - Cullum, C Munro
AU  - Cullum CM
FAU - Diaz-Arrastia, Ramon
AU  - Diaz-Arrastia R
CN  - Texas Alzheimer's Research Consortium
LA  - eng
GR  - P30 AG012300/AG/NIA NIH HHS/United States
GR  - P30 AG012300-15/AG/NIA NIH HHS/United States
GR  - P30AG12300/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunoassay/methods
MH  - Male
MH  - Mental Status Schedule
MH  - Middle Aged
PMC - PMC2787708
MID - NIHMS99051
FIR - Doody, Rachelle
IR  - Doody R
FIR - Capriles, Violeta
IR  - Capriles V
FIR - Darby, Eveleen
IR  - Darby E
FIR - Szigeti, Kinga
IR  - Szigeti K
FIR - Williams, Benjamin
IR  - Williams B
FIR - Zhang, Yan
IR  - Zhang Y
FIR - Fairchild, Thomas
IR  - Fairchild T
FIR - Knebl, Janice
IR  - Knebl J
FIR - Mains, Douglas
IR  - Mains D
FIR - Alvarez, Lisa
IR  - Alvarez L
FIR - Adams, Perrie
IR  - Adams P
FIR - Rosenberg, Roger
IR  - Rosenberg R
FIR - Reisch, Joan
IR  - Reisch J
FIR - Svetlik, Doris
IR  - Svetlik D
FIR - Williams, Keverly
IR  - Williams K
FIR - Naylor, Joey
IR  - Naylor J
FIR - Smith, Janet
IR  - Smith J
EDAT- 2009/04/14 09:00
MHDA- 2009/12/17 06:00
PMCR- 2009/12/03
CRDT- 2009/04/14 09:00
PHST- 2009/04/14 09:00 [entrez]
PHST- 2009/04/14 09:00 [pubmed]
PHST- 2009/12/17 06:00 [medline]
PHST- 2009/12/03 00:00 [pmc-release]
AID - 052G70T078857553 [pii]
AID - 10.3233/JAD-2009-1051 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2009;17(2):337-41. doi: 10.3233/JAD-2009-1051.