PMID- 19364281
OWN - NLM
STAT- MEDLINE
DCOM- 20091223
LR  - 20130405
IS  - 1937-335X (Electronic)
IS  - 1937-3341 (Linking)
VI  - 15
IP  - 10
DP  - 2009 Oct
TI  - Effect of polymer molecular weight on the bone biological activity of 
      biodegradable polymer/calcium phosphate cement composites.
PG  - 3183-91
LID - 10.1089/ten.TEA.2008.0694 [doi]
AB  - Previous studies demonstrated that the addition of biodegradable polymer 
      microparticles to calcium phosphate (CaP) cement improves the cement's 
      degradative behavior without affecting its handling characteristics, especially 
      its injectability and moldability. We investigated the influence of molecular 
      weight of polymeric microparticles included in CaP cement on implant degradation 
      and bone formation in critical-sized defects. Forty rats received cranial defects 
      filled with formulations of CaP cement and poly(DL-lactic-co-glycolic acid) 
      (PLGA) microparticles. Microparticles consisted of 100% high- (HMW) or 
      low-molecular-weight (LMW) PLGA or mixtures of these (25%, 50%, or 75%). 
      Implantation time was 12 weeks. Porosity measurements showed that the 100% HMW 
      group was significantly less porous than the other groups. Histology and 
      histomorphometry revealed significantly greater implant degradation in the 100% 
      LMW group. Defect bridging was mainly seen in the 75% and 100% LMW groups, with 
      the highest amount of bone in the 100% LMW formulation. These results suggest 
      that LMW PLGA microparticles are associated with better bone formation than HMW 
      PLGA, which is most likely explained by the greater degradation of LMW PLGA 
      microparticles. In conclusion, CaP cement composites with high percentages of LMW 
      PLGA microparticles show good bone transductive behavior, with complete defect 
      bridging. The 100% LMW group turned out to be the best formulation.
FAU - Bodde, Esther W H
AU  - Bodde EW
AD  - Department of Periodontology and Biomaterials, Radboud University Nijmegen 
      Medical Center, Nijmegen, The Netherlands.
FAU - Habraken, Wouter J E M
AU  - Habraken WJ
FAU - Mikos, Antonios G
AU  - Mikos AG
FAU - Spauwen, Paul H M
AU  - Spauwen PH
FAU - Jansen, John A
AU  - Jansen JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tissue Eng Part A
JT  - Tissue engineering. Part A
JID - 101466659
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Cements)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Polymers)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - Bone Cements/*chemistry
MH  - Calcium Phosphates/*chemistry
MH  - *Molecular Weight
MH  - Polymers/*chemistry
MH  - Rats
MH  - Tissue Engineering/*methods
EDAT- 2009/04/15 09:00
MHDA- 2009/12/24 06:00
CRDT- 2009/04/15 09:00
PHST- 2009/04/15 09:00 [entrez]
PHST- 2009/04/15 09:00 [pubmed]
PHST- 2009/12/24 06:00 [medline]
AID - 10.1089/ten.TEA.2008.0694 [doi]
PST - ppublish
SO  - Tissue Eng Part A. 2009 Oct;15(10):3183-91. doi: 10.1089/ten.TEA.2008.0694.