PMID- 19364369
OWN - NLM
STAT- MEDLINE
DCOM- 20090709
LR  - 20221207
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 16
IP  - 3
DP  - 2009 Mar
TI  - HLA-DRB1 and multiple sclerosis in Argentina.
PG  - 427-9
LID - 10.1111/j.1468-1331.2008.02523.x [doi]
AB  - BACKGROUND: The association of multiple sclerosis (MS) with HLA DR subtypes, and 
      particularly human leukocyte antigen (HLA)-DRB1*15 has been a consistent finding 
      across nearly all Caucasian MS populations. In South America, scarce data exist 
      about this issue. As the complete characterization of the HLA association range 
      around the world is important to understand the role of this locus in MS 
      susceptibility, we analyzed the frequency of HLA-DRB1* allelic groups in an MS 
      population in Argentina. METHODS: HLA-DRB1 locus was genotyped using PCR and 
      sequence-specific primer amplification in 61 MS patients born in Buenos Aires, 
      Argentina and 1216 healthy controls. Allele frequencies were compared between 
      groups. RESULTS: The HLA-DRB1*15 allele frequency significantly differed between 
      controls and patients (13.5% and 33.9% respectively, P < 0.001, OR 2.51, 95% CI: 
      1.7-3.0). The other allele frequencies did not show significant differences 
      between patients and controls. CONCLUSIONS: The present HLA class II population 
      study is in accordance with other Caucasian MS surveys which have found that 
      HLA-DRB1*15 allele is strongly associated with MS disease. In Argentina, this is 
      the first study performed to analyze the association of HLA-DRB1*15 and MS 
      susceptibility in a Caucasian population and therefore contributes with new data 
      to the immunogenomic global MS map.
FAU - Patrucco, L
AU  - Patrucco L
AD  - MS Section, Hospital Italiano Buenos Aires, Argentina.
FAU - Larriba, J
AU  - Larriba J
FAU - Redal, M A
AU  - Redal MA
FAU - Rojas, J I
AU  - Rojas JI
FAU - Argibay, P F
AU  - Argibay PF
FAU - Cristiano, E
AU  - Cristiano E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Argentina
MH  - Gene Frequency
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - White People/genetics
EDAT- 2009/04/15 09:00
MHDA- 2009/07/10 09:00
CRDT- 2009/04/15 09:00
PHST- 2009/04/15 09:00 [entrez]
PHST- 2009/04/15 09:00 [pubmed]
PHST- 2009/07/10 09:00 [medline]
AID - ENE2523 [pii]
AID - 10.1111/j.1468-1331.2008.02523.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2009 Mar;16(3):427-9. doi: 10.1111/j.1468-1331.2008.02523.x.