PMID- 19364514
OWN - NLM
STAT- MEDLINE
DCOM- 20091013
LR  - 20211203
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 7
DP  - 2009 Jul
TI  - HLA polymorphism in six Malay subethnic groups in Malaysia.
PG  - 518-26
LID - 10.1016/j.humimm.2009.04.003 [doi]
AB  - In this study, human leukocyte antigen (HLA) class I and II were examined through 
      sequence-specific primer typing in 176 unrelated individuals from six Malay 
      subethnic groups of Peninsular Malaysia: Kelantan (n = 25), Minangkabau (34), 
      Jawa (30), Bugis (31), Banjar (33), and Rawa (23). The most common HLA alleles in 
      all groups were A*24 (26-41%), Cw*07 (24-32%), B*15 (22-30%), DRB1*12 (15-36%), 
      and DQB1*03 (25-51%). The Malay subethnic groups studied demonstrated a close 
      relationship to each other and to other Asian populations, despite specific 
      differences between them. Banjar, Bugis, and Jawa Malays demonstrated no 
      significant difference from each other, which could be a result of their related 
      origin from the islands around the Java Sea. These three Malay subethnic groups 
      were then collapsed into one group, which also helped to increase the sample 
      number and sharpen statistical results. Minangkabau and Rawa Malays exhibited 
      high similarities in allele group and haplotype frequencies, which could be a 
      consequence of their common origin from Sumatera. Kelantan Malays, in addition to 
      their statistically significant differences compared with the other groups, also 
      exhibited differences on the most frequent haplotypes, which are almost absent in 
      the other subethnic groups studied.
FAU - Edinur, Hisham Atan
AU  - Edinur HA
AD  - School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang 
      Kerian, Kelantan, Malaysia.
FAU - Zafarina, Zainuddin
AU  - Zafarina Z
FAU - Spinola, Helder
AU  - Spinola H
FAU - Nurhaslindawaty, Abd Rashid
AU  - Nurhaslindawaty AR
FAU - Panneerchelvam, Sundararajulu
AU  - Panneerchelvam S
FAU - Norazmi, Mohd-Nor
AU  - Norazmi MN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090411
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Analysis of Variance
MH  - Ethnicity/*genetics
MH  - Gene Frequency
MH  - Geography
MH  - HLA Antigens/classification/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Malaysia
MH  - Phylogeny
MH  - *Polymorphism, Genetic
EDAT- 2009/04/15 09:00
MHDA- 2009/10/14 06:00
CRDT- 2009/04/15 09:00
PHST- 2008/09/29 00:00 [received]
PHST- 2009/03/26 00:00 [revised]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2009/04/15 09:00 [entrez]
PHST- 2009/04/15 09:00 [pubmed]
PHST- 2009/10/14 06:00 [medline]
AID - S0198-8859(09)00091-3 [pii]
AID - 10.1016/j.humimm.2009.04.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Jul;70(7):518-26. doi: 10.1016/j.humimm.2009.04.003. Epub 2009 
      Apr 11.