PMID- 19364518
OWN - NLM
STAT- MEDLINE
DCOM- 20091013
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 7
DP  - 2009 Jul
TI  - MICA-HLA-B haplotype diversity and linkage disequilibrium in a population of 
      Jewish descent from Majorca (the Balearic Islands).
PG  - 513-7
LID - 10.1016/j.humimm.2009.04.005 [doi]
AB  - The major histocompatibility complex class I chain-related A (MICA) gene is 
      located 46 kb centromeric of human leukocyte antigen (HLA)-B and is highly 
      polymorphic, similar to HLA genes. This allelic variation may influence the 
      affinity of MICA molecules to their receptor on natural killer, gammadelta T and 
      CD8+ T cells, NKG2D, and the immune response to organ transplantation and disease 
      susceptibility. In the present study, we typed MICA and HLA-B polymorphisms in 95 
      individuals from a population of Jewish descent (Chuetas) and 195 individuals of 
      Caucasian origin from Majorca (the Balearic Islands). MICA*008, -*004, and -*002 
      were the most common alleles and accounted for 53 and 60% in Chuetas and 
      Majorcans, respectively. Other common alleles (frequency >5%) were MICA*016, 
      -*009, -*012, -*007, and -*017 in Chuetas and -*009, -*001, and -*018 in 
      Majorcans. We also studied two-locus haplotype diversity and linkage 
      disequilibrium (LD). Both populations presented haplotypes with significant LD 
      that were shared by other Caucasians populations, but we reported particular 
      haplotypes in the Chueta group: MICA*002-HLA-B*38, MICA*016-HLA-B*35, 
      MICA*012-HLA-B*55, and MICA*017-HLA-B*57. These haplotypes were not reported in 
      other studies at high frequencies. In conclusion, the Chueta population presents 
      a particular genetic pool but has affinities with the host population.
FAU - Cambra, Ana
AU  - Cambra A
AD  - Immunology Service, Hospital Universitari Son Dureta, Palma de Mallorca, Spain.
FAU - Munoz-Saa, Ivan
AU  - Munoz-Saa I
FAU - Crespi, Catalina
AU  - Crespi C
FAU - Serra, Antonia
AU  - Serra A
FAU - Etxagibel, Aitziber
AU  - Etxagibel A
FAU - Matamoros, Nuria
AU  - Matamoros N
FAU - Mila, Joan
AU  - Mila J
FAU - Julia, Maria Rosa
AU  - Julia MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090411
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Gene Frequency
MH  - Genetic Variation
MH  - HLA-B Antigens/*genetics
MH  - *Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Jews/*genetics
MH  - *Linkage Disequilibrium
MH  - Polymorphism, Genetic
MH  - Spain
MH  - White People/genetics
EDAT- 2009/04/15 09:00
MHDA- 2009/10/14 06:00
CRDT- 2009/04/15 09:00
PHST- 2008/12/23 00:00 [received]
PHST- 2009/03/23 00:00 [revised]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2009/04/15 09:00 [entrez]
PHST- 2009/04/15 09:00 [pubmed]
PHST- 2009/10/14 06:00 [medline]
AID - S0198-8859(09)00093-7 [pii]
AID - 10.1016/j.humimm.2009.04.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Jul;70(7):513-7. doi: 10.1016/j.humimm.2009.04.005. Epub 2009 
      Apr 11.