PMID- 19366080
OWN - NLM
STAT- MEDLINE
DCOM- 20090512
LR  - 20090415
IS  - 1220-4749 (Print)
IS  - 1220-4749 (Linking)
VI  - 46
IP  - 3
DP  - 2008
TI  - Risk factors for heart failure in patients with one prior myocardial infarction 
      episode.
PG  - 213-21
AB  - BACKGROUND AND AIM: Myocardial infarction is an important risk factor for HF, 
      increasing risk 2- to 3-fold. Other identified classical risk factors for HF 
      include left ventricular hypertrophy, valvular heart disease, hypertension, 
      diabetes mellitus, cigarette smoking, obesity, and dyslipidaemia. New mechanisms, 
      such as insulin resistance, inflammation, and oxidative stress, have been 
      investigated, but the importance of many of these mechanisms is largely 
      unexplored in patients of HF. Our aim was to evaluate the factors involved in 
      heart failure installation in patients with prior myocardial infarction. METHODS: 
      We performed a cross-sectional study including 144 patients presenting old, 
      certified myocardial infarction. Patients were divided into two groups according 
      to presence/absence of heart failure, as certified by New York Heart Association 
      (NYHA) classification of heart and of echocardiography criteria by left 
      ventricular ejection fraction < 40%. Univariate and multivariate models were 
      performed to identify the independent predictors of heart failure. Also, receiver 
      operating characteristic analysis doubled by chi square test for trend was 
      performed to analyze the risk impact of each identified predictor. RESULTS: 
      Univariate between groups comparison was significant for hypertension (p = 
      0.001), diabetes mellitus (p < 0.001), smoking status (p < 0.001), obesity (p = 
      0.027), waist circumference (p < 0.001), and levels of C-reactive protein (p < 
      0.001), total cholesterol (p = 0.008), triglycerides (p = 0.003), HDL-Cholesterol 
      (p < 0.001), glycaemia (p < 0.001) and brain natriuretic peptide (p < 0.001). 
      Multivariate analysis selected C-reactive protein (OR = 2.7, 95% CI = 1.9-4.9, p 
      < 0.001), glycaemia (OR = 2.1, 95% CI = 1.2-4.5, p = 0.027) and HDL-Cholesterol 
      (OR = 0.7, 95% CI = 0.3-0.9, p = 0.035) as independent predictors. Separate 
      across quintile test for trend revealed that the highest risk is added by levels 
      of C-reactive protein levels > = 24mg/dL, followed by glycaemia levels > = 114 
      mg/dL and HDL-Cholesterol < 32 mg/dL. CONCLUSIONS: Reducing of C-reactive protein 
      and glycaemia levels, as well as increasing the level of HDL-Cholesterol may add 
      a great benefit in reducing heart failure installation risk in patients with 
      myocardial infarction.
FAU - Mocan, Teodora
AU  - Mocan T
AD  - Department of Normal Morphology and Functions, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, Cluj-Napoca, Romania. teodora_mocan@yahoo.com
FAU - Agoston-Coldea, Lucia
AU  - Agoston-Coldea L
FAU - Gatfosse, M
AU  - Gatfosse M
FAU - Rosenstingl, Sophie
AU  - Rosenstingl S
FAU - Mocan, L C
AU  - Mocan LC
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Rom J Intern Med
JT  - Romanian journal of internal medicine = Revue roumaine de medecine interne
JID - 9304507
RN  - 0 (Cholesterol, HDL)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - C-Reactive Protein/analysis
MH  - Cholesterol, HDL/blood
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Heart Failure/blood/*etiology
MH  - Humans
MH  - Hyperglycemia
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*complications
MH  - Odds Ratio
MH  - ROC Curve
MH  - Risk Factors
EDAT- 2008/01/01 00:00
MHDA- 2009/05/13 09:00
CRDT- 2009/04/16 09:00
PHST- 2009/04/16 09:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2009/05/13 09:00 [medline]
PST - ppublish
SO  - Rom J Intern Med. 2008;46(3):213-21.