PMID- 19366919
OWN - NLM
STAT- MEDLINE
DCOM- 20090814
LR  - 20231103
IS  - 1098-6618 (Electronic)
IS  - 0893-8512 (Print)
IS  - 0893-8512 (Linking)
VI  - 22
IP  - 2
DP  - 2009 Apr
TI  - HLA and infectious diseases.
PG  - 370-85, Table of Contents
LID - 10.1128/CMR.00048-08 [doi]
AB  - Following their discovery in the early 1970s, classical human leukocyte antigen 
      (HLA) loci have been the prototypical candidates for genetic susceptibility to 
      infectious disease. Indeed, the original hypothesis for the extreme variability 
      observed at HLA loci (H-2 in mice) was the major selective pressure from 
      infectious diseases. Now that both the human genome and the molecular basis of 
      innate and acquired immunity are understood in greater detail, do the classical 
      HLA loci still stand out as major genes that determine susceptibility to 
      infectious disease? This review looks afresh at the evidence supporting a role 
      for classical HLA loci in susceptibility to infectious disease, examines the 
      limitations of data reported to date, and discusses current advances in 
      methodology and technology that will potentially lead to greater understanding of 
      their role in infectious diseases in the future.
FAU - Blackwell, Jenefer M
AU  - Blackwell JM
AD  - Telethon Institute for Child Health Research, Centre for Child Health Research, 
      The University of Western Australia, P.O. Box 855, West Perth, Western Australia, 
      Australia 6872. jmb37@cam.ac.uk
FAU - Jamieson, Sarra E
AU  - Jamieson SE
FAU - Burgner, David
AU  - Burgner D
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - R01 AI076233/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Clin Microbiol Rev
JT  - Clinical microbiology reviews
JID - 8807282
RN  - 0 (HLA Antigens)
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Communicable Diseases/*genetics/*immunology
MH  - Genetic Predisposition to Disease
MH  - HIV Infections/genetics/immunology
MH  - *HLA Antigens/genetics/immunology
MH  - Helminthiasis/genetics/immunology
MH  - Humans
MH  - Mycobacterium Infections/genetics/immunology
MH  - Protozoan Infections/genetics/immunology
MH  - Vaccines/immunology
PMC - PMC2668228
EDAT- 2009/04/16 09:00
MHDA- 2009/08/15 09:00
PMCR- 2010/04/01
CRDT- 2009/04/16 09:00
PHST- 2009/04/16 09:00 [entrez]
PHST- 2009/04/16 09:00 [pubmed]
PHST- 2009/08/15 09:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 22/2/370 [pii]
AID - 0048-08 [pii]
AID - 10.1128/CMR.00048-08 [doi]
PST - ppublish
SO  - Clin Microbiol Rev. 2009 Apr;22(2):370-85, Table of Contents. doi: 
      10.1128/CMR.00048-08.