PMID- 19367049
OWN - NLM
STAT- MEDLINE
DCOM- 20090727
LR  - 20190608
IS  - 1880-8026 (Electronic)
IS  - 0019-8366 (Linking)
VI  - 47
IP  - 2
DP  - 2009 Apr
TI  - Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl on postnatal 
      development and thyroid function in rat offspring.
PG  - 189-97
AB  - Exposure to polychlorobiphenyls (PCBs) has been reported to affect endocrine 
      glands; however, little is known about the precise toxicological properties of 
      individual PCBs. We determined whether prenatal exposure to 
      2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153), a di-ortho-substituted non-coplanar 
      congener, affects postnatal development in rat offspring. Pregnant Sprague-Dawley 
      rats were given PCB 153 (0, 1, or 4 mg/kg/d) orally from gestational day (GD) 10 
      to 16, and somatic parameters and thyroid functions in offspring were examined. 
      We found no dose-dependent changes in body weight, body length, tail length, or 
      weight of liver, kidney, testis, seminal vesicle, prostate, ovary, relative organ 
      weight, anogenital distance (AGD), or AGD index in offspring at 1, 3 or 9 wk of 
      age. We observed no compound-related changes in the plasma concentrations of 
      thyroxine (T(4)), tri-iodothyronine (T(3)) or thyroid-stimulating hormone (TSH), 
      although there was a significant difference in T(3) only in 1-wk-old males. In 
      addition, thyroid glands from PCB 153 groups had normal T(4) responses to 
      exogenous TSH in vivo. These findings suggest that low doses of PCB 153 given 
      prenatally (GD 10-16, 1-4 mg/kg/d) might have little effect on postnatal somatic 
      growth or thyroid development of male and female rat offspring under the 
      experimental conditions of the present study.
FAU - Kobayashi, Kenichi
AU  - Kobayashi K
AD  - National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-Ku, 
      Kawasaki 214-8585, Japan.
FAU - Miyagawa, Muneyuki
AU  - Miyagawa M
FAU - Wang, Rui-Sheng
AU  - Wang RS
FAU - Suda, Megumi
AU  - Suda M
FAU - Sekiguchi, Soichiro
AU  - Sekiguchi S
FAU - Honma, Takeshi
AU  - Honma T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Ind Health
JT  - Industrial health
JID - 2985065R
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - Q51BO43MG4 (Thyroxine)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Environmental Monitoring
MH  - Female
MH  - Growth and Development/*drug effects
MH  - Kidney/pathology
MH  - Liver/pathology
MH  - Male
MH  - Organ Size/drug effects
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prostate/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seminal Vesicles/pathology
MH  - Testis/pathology
MH  - Thyroid Function Tests
MH  - Thyroid Gland/*drug effects
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
EDAT- 2009/04/16 09:00
MHDA- 2009/07/28 09:00
CRDT- 2009/04/16 09:00
PHST- 2009/04/16 09:00 [entrez]
PHST- 2009/04/16 09:00 [pubmed]
PHST- 2009/07/28 09:00 [medline]
AID - JST.JSTAGE/indhealth/47.189 [pii]
AID - 10.2486/indhealth.47.189 [doi]
PST - ppublish
SO  - Ind Health. 2009 Apr;47(2):189-97. doi: 10.2486/indhealth.47.189.