PMID- 19368899
OWN - NLM
STAT- MEDLINE
DCOM- 20091109
LR  - 20240324
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 66
IP  - 6
DP  - 2009 Sep 15
TI  - Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement 
      in schizophrenia?
PG  - 549-53
LID - 10.1016/j.biopsych.2009.02.017 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a critical role in 
      neurodevelopment and plasticity; decreased BDNF functioning may contribute to the 
      pathogenesis of schizophrenia. However, BDNF levels are not static; in animal 
      experiments, brain BDNF increases during spatial learning, and in clinical 
      depression, successful antidepressant treatment raises serum BDNF. We asked: 
      would neuroplasticity-based cognitive training in schizophrenia result in 
      increased serum BDNF? METHODS: Fifty-six schizophrenia outpatients and 16 matched 
      healthy comparison subjects were assessed on baseline cognitive performance and 
      serum BDNF. Schizophrenia subjects were randomly assigned to either 50 hours (10 
      weeks) of computerized auditory training or a computer game control condition, 
      followed by reassessment of cognition and serum BDNF. RESULTS: At baseline, 
      schizophrenia participants had significantly lower-than-normal serum BDNF. 
      Schizophrenia subjects who engaged in computerized cognitive training designed to 
      improve auditory processing showed significant cognitive gains and a significant 
      increase in serum BDNF compared with subjects who played computer games. This 
      increase was evident after 2 weeks of training, and after 10 weeks in the active 
      condition, subjects "normalized" their mean serum BDNF levels, whereas the 
      control group showed no change. In the active condition, change in BDNF was 
      significantly associated with improved quality of life. CONCLUSIONS: Serum BDNF 
      levels are significantly increased in clinically stable, chronically ill 
      schizophrenia subjects after neuroplasticity-based cognitive training, but not 
      after computer games. Serum BDNF levels may serve as a peripheral biomarker for 
      the effects of intensive cognitive training and may provide a useful tool for the 
      evaluation of cognitive enhancement methods in schizophrenia.
FAU - Vinogradov, Sophia
AU  - Vinogradov S
AD  - Department of Psychiatry, School of Medicine, University of California-San 
      Francisco, California 94121, USA. Sophia.vinogradov@ucsf.edu
FAU - Fisher, Melissa
AU  - Fisher M
FAU - Holland, Christine
AU  - Holland C
FAU - Shelly, Wendy
AU  - Shelly W
FAU - Wolkowitz, Owen
AU  - Wolkowitz O
FAU - Mellon, Synthia H
AU  - Mellon SH
LA  - eng
GR  - R01 MH068725/MH/NIMH NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - R01 MH068725-01A1/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090415
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cognition Disorders/*blood/*rehabilitation
MH  - Cognitive Behavioral Therapy/*methods
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life
MH  - Schizophrenia/complications
MH  - *Schizophrenic Psychology
MH  - Therapy, Computer-Assisted/methods
MH  - Time Factors
PMC - PMC4691262
MID - NIHMS489421
EDAT- 2009/04/17 09:00
MHDA- 2009/11/10 06:00
PMCR- 2015/12/26
CRDT- 2009/04/17 09:00
PHST- 2008/11/04 00:00 [received]
PHST- 2009/01/30 00:00 [revised]
PHST- 2009/02/22 00:00 [accepted]
PHST- 2009/04/17 09:00 [entrez]
PHST- 2009/04/17 09:00 [pubmed]
PHST- 2009/11/10 06:00 [medline]
PHST- 2015/12/26 00:00 [pmc-release]
AID - S0006-3223(09)00230-3 [pii]
AID - 10.1016/j.biopsych.2009.02.017 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2009 Sep 15;66(6):549-53. doi: 10.1016/j.biopsych.2009.02.017. 
      Epub 2009 Apr 15.