PMID- 19368923
OWN - NLM
STAT- MEDLINE
DCOM- 20091207
LR  - 20221207
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 206
IP  - 2
DP  - 2009 Oct
TI  - Increased glycated albumin and decreased esRAGE levels are related to 
      angiographic severity and extent of coronary artery disease in patients with type 
      2 diabetes.
PG  - 540-5
LID - 10.1016/j.atherosclerosis.2008.12.045 [doi]
AB  - OBJECTIVE: This cross-sectional study aimed at evaluating the possible 
      association of serum levels of glycated albumin (GA) and endogenous secretory 
      RAGE (esRAGE) with angiographically significant coronary artery disease (CAD) in 
      patients with type 2 diabetes mellitus (T2DM) and non-diabetic patients. METHODS: 
      Serum levels of GA, esRAGE, and inflammatory markers were measured in 1320 
      patients undergoing coronary angiography from three large districts in Shanghai. 
      Patients were divided into four groups based on the presence/absence of T2DM and 
      of significant CAD (diameter stenosis >or=70%). RESULTS: Serum levels of GA, 
      high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor (TNF)-alpha 
      and interleukin (IL)-6 were significantly higher and, in contrast, serum esRAGE 
      levels were lower in patients with both T2DM and significant CAD than in all 
      other groups (all P<0.01), whereas there were no significant differences in GA 
      and esRAGE levels between non-diabetic patients with CAD and those without. Serum 
      GA and esRAGE levels correlated with angiographic CAD severity (P=0.031 and 
      P=0.001), extent (both P<0.001) and number of diseased coronary arteries (both 
      P<0.001) in diabetic CAD patients. At multivariable regression analysis, male 
      gender, age, hypertension, cigarette smoking, HDL-C, lipoprotein (a), GA, esRAGE, 
      hsCRP and TNF-alpha were all independent determinants of significant CAD in 
      diabetic patients. Moreover, male gender, age, hypertension, lipoprotein (a), GA 
      and esRAGE remained independently associated with three-vessel disease. 
      CONCLUSION: Patients with T2DM and CAD feature elevated serum GA and decreased 
      serum esRAGE levels. Here serum GA and esRAGE levels are associated with 
      angiographic extent and severity of CAD.
FAU - Lu, Lin
AU  - Lu L
AD  - Department of Cardiology, Rui Jin Hospital, 197 Rui Jin Road II, Shanghai 200025, 
      PR China.
FAU - Pu, Li Jin
AU  - Pu LJ
FAU - Zhang, Qi
AU  - Zhang Q
FAU - Wang, Ling Jie
AU  - Wang LJ
FAU - Kang, Sheng
AU  - Kang S
FAU - Zhang, Rui Yan
AU  - Zhang RY
FAU - Chen, Qiu Jing
AU  - Chen QJ
FAU - Wang, Ji Guang
AU  - Wang JG
FAU - De Caterina, Raffaele
AU  - De Caterina R
FAU - Shen, Wei Feng
AU  - Shen WF
LA  - eng
PT  - Journal Article
DEP - 20090321
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Serum Albumin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - C-Reactive Protein/metabolism
MH  - China
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/complications
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Glycation End Products, Advanced/blood
MH  - Humans
MH  - Interleukin-6/blood
MH  - Male
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*blood
MH  - Serum Albumin/*metabolism
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Glycated Serum Albumin
EDAT- 2009/04/17 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/04/17 09:00
PHST- 2008/08/28 00:00 [received]
PHST- 2008/12/27 00:00 [revised]
PHST- 2008/12/28 00:00 [accepted]
PHST- 2009/04/17 09:00 [entrez]
PHST- 2009/04/17 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0021-9150(09)00216-0 [pii]
AID - 10.1016/j.atherosclerosis.2008.12.045 [doi]
PST - ppublish
SO  - Atherosclerosis. 2009 Oct;206(2):540-5. doi: 
      10.1016/j.atherosclerosis.2008.12.045. Epub 2009 Mar 21.