PMID- 1936984
OWN - NLM
STAT- MEDLINE
DCOM- 19911205
LR  - 20190912
IS  - 0016-6723 (Linking)
VI  - 58
IP  - 1
DP  - 1991 Aug
TI  - Growth hormone and insulin-like growth factor-I measurements in high growth (hg) 
      mice.
PG  - 67-74
AB  - Effects of a recessive gene causing high growth (hg) were studied on two major 
      components of the growth axis in mice. Plasma and pituitary levels of growth 
      hormone and plasma levels of insulin-like growth factor I (IGF-I) were measured 
      in three lines homozygous for hg, each compared with a control line of alike 
      genetic background but wild type for the hg locus (Hg). Line Gh (hghg) and line 
      GH (HgHg) are from a line which had undergone long-term selection for high 
      postweaning weight gain; line Ch (hghg) and line CH (HgHg) were extracted from 
      the second backcross of Gh to C57BL/6J; line L54 (hghg) was from the sixth 
      backcross to C57BL/6J (B6) (HgHg). Pituitary GH levels and plasma IGF-I levels 
      were measured in both sexes at 3, 4.5, 6 and 9 wk of age. Plasma growth hormone 
      was measured in 8- to 12-wk-old males at hourly intervals from 08.00 to 17.00. 
      Body weight in lines homozygous for hg at 6 and 9 wk of age was 10-30% greater 
      than in control lines. The ontogeny of this increased growth depended on genetic 
      background. Pituitary growth hormone content was 52% lower in the two hghg lines 
      measured (lines Ch and Gh) than in control lines at 4.5, 6 and 9 wk. Plasma 
      growth hormone levels were also much lower in hg mice, with values only 20-30% of 
      those in their respective controls. hg lines showed consistently low plasma 
      growth hormone levels throughout the 9 hr sampling period, while control lines 
      expressed the characteristic pulsatile hormone secretion.(ABSTRACT TRUNCATED AT 
      250 WORDS)
FAU - Medrano, J F
AU  - Medrano JF
AD  - Department of Animal Science, University of California, Davis 95616-8521.
FAU - Pomp, D
AU  - Pomp D
FAU - Sharrow, L
AU  - Sharrow L
FAU - Bradford, G E
AU  - Bradford GE
FAU - Downs, T R
AU  - Downs TR
FAU - Frohman, L A
AU  - Frohman LA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Genet Res
JT  - Genetical research
JID - 0370741
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
GS  - hg
MH  - Animals
MH  - Body Weight/genetics
MH  - Female
MH  - Gene Expression Regulation
MH  - Genes, Recessive
MH  - Growth/*genetics
MH  - Growth Hormone/*genetics
MH  - Insulin-Like Growth Factor I/*genetics
MH  - Male
MH  - Mice
MH  - Pituitary Gland/metabolism
MH  - Statistics as Topic
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.1017/s0016672300029621 [doi]
PST - ppublish
SO  - Genet Res. 1991 Aug;58(1):67-74. doi: 10.1017/s0016672300029621.