PMID- 19371767
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20151119
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 33
IP  - 5
DP  - 2009 Aug 1
TI  - Reduced platelet BDNF level in patients with major depression.
PG  - 849-53
LID - 10.1016/j.pnpbp.2009.04.002 [doi]
AB  - Serum and plasma brain-derived neurotrophic factor (BDNF) levels as well as brain 
      BDNF have previously been shown to be decreased in patients with major depressive 
      disorder (MDD). We explored whether platelet BDNF levels, circulating stored 
      BDNF, would be lower in MDD patients than in normal controls. BDNF levels were 
      examined in platelet-rich plasma (PRP) and platelet-poor plasma (PPP) in 20 
      hospitalized non-suicidal MDD patients, 20 recent-suicidal MDD patients, and 20 
      normal controls. Platelet BDNF content was calculated by subtracting PPP BDNF 
      level from PRP BDNF level, and dividing the result by the total platelet count, 
      and it was expressed as pg/10(6) platelets. Individuals were evaluated using a 
      Structured Clinical Interview for DSM-IV and a Hamilton Depression Rating Scale. 
      Platelet BDNF contents were significantly lower in non-suicidal patients 
      (3.09+/-2.53 pg/10(6) platelets) and recent-suicidal MDD patients (3.16+/-1.99 
      pg/10(6) platelets) than in healthy controls (6.17+/-2.64 pg/10(6) platelets) 
      (p<0.01). However, platelet BDNF contents had no significant differences between 
      non-suicidal and recent-suicidal patients. PRP BDNF levels were also 
      significantly lower in non-suicidal and suicidal MDD patients than in healthy 
      controls (p=0.029), while PPP BDNF had no significant difference between 3 groups 
      (p=0.971). Our findings suggest that there is a decrease in the platelet BDNF of 
      patients with major depression. Reduced platelet BDNF contents as circulating 
      stored BDNF could be associated with lower serum BDNF level in patients with 
      major depression.
FAU - Lee, Bun-Hee
AU  - Lee BH
AD  - Department of Psychiatry, College of Medicine, Korea University Ansan Hospital, 
      Republic of Korea.
FAU - Kim, Yong-Ku
AU  - Kim YK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090414
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Platelets/*metabolism
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/biosynthesis/*blood
MH  - Depressive Disorder, Major/*blood/diagnosis/psychology
MH  - Down-Regulation/*physiology
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Suicide/psychology
MH  - Young Adult
EDAT- 2009/04/18 09:00
MHDA- 2010/03/13 06:00
CRDT- 2009/04/18 09:00
PHST- 2009/01/25 00:00 [received]
PHST- 2009/04/07 00:00 [revised]
PHST- 2009/04/07 00:00 [accepted]
PHST- 2009/04/18 09:00 [entrez]
PHST- 2009/04/18 09:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - S0278-5846(09)00111-0 [pii]
AID - 10.1016/j.pnpbp.2009.04.002 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):849-53. doi: 
      10.1016/j.pnpbp.2009.04.002. Epub 2009 Apr 14.