PMID- 19372295
OWN - NLM
STAT- MEDLINE
DCOM- 20090508
LR  - 20171114
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 80
IP  - 5
DP  - 2009 May
TI  - Marked increase in cerebrospinal fluid glial fibrillar acidic protein in 
      neuromyelitis optica: an astrocytic damage marker.
PG  - 575-7
LID - 10.1136/jnnp.2008.150698 [doi]
AB  - BACKGROUND: Neuromyelitis optica (NMO) is a neurological inflammatory disease 
      associated with autoimmunity to aquaporin 4, predominantly localised in 
      astrocytic foot processes. Recent studies have revealed that loss of aquaporin 4 
      and glial fibrillar acidic protein (GFAP) is a prominent feature of NMO lesions, 
      suggesting astrocytic impairment. OBJECTIVE: To reveal a useful clinical 
      biomarker of NMO. METHODS: Enzyme-linked immunosorbent assays were carried out 
      for astrocytic markers GFAP and S100B in CSFs, obtained from the patients with 
      NMO (n = 10) and multiple sclerosis (MS) (n = 10) manifesting acute myelitis, 
      acute disseminated encephalomyelitis (ADEM) (n = 3), spinal infarction (n = 3), 
      and other neurological diseases (OND) (n = 5). RESULTS: The CSF-GFAP levels 
      during relapse in NMO (7666.0 (SD 15 266.5) ng/ml) were significantly over 
      several thousand times higher than those in MS (0.7 (1.5)) or OND (0.6 (0.3)), 
      and considerably higher than those in spinal infarction (354.7 (459.0)) and ADEM 
      (0.4 (0.2)). They returned close to normal levels along with clinical improvement 
      soon after corticosteroid therapy in NMO. There were strong correlations between 
      the CSF-GFAP or S100B levels and expanded disability status scales or spinal 
      lesion length in NMO (r>0.9). CONCLUSIONS: CSF-GFAP and S100B may be clinically 
      useful biomarkers in NMO, and astrocytic damage is strongly suggested in the 
      acute phase of NMO.
FAU - Misu, T
AU  - Misu T
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, 
      Sendai, Japan. misu@em.neurol.med.tohoku.ac.jp
FAU - Takano, R
AU  - Takano R
FAU - Fujihara, K
AU  - Fujihara K
FAU - Takahashi, T
AU  - Takahashi T
FAU - Sato, S
AU  - Sato S
FAU - Itoyama, Y
AU  - Itoyama Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Aquaporin 4)
RN  - 0 (Biomarkers)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aquaporin 4/genetics
MH  - Astrocytes/*pathology
MH  - Biomarkers
MH  - Encephalomyelitis, Acute Disseminated/cerebrospinal fluid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glial Fibrillary Acidic Protein/*cerebrospinal fluid
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuromyelitis Optica/*cerebrospinal fluid
MH  - S100 Proteins/cerebrospinal fluid
MH  - Spinal Cord/pathology
EDAT- 2009/04/18 09:00
MHDA- 2009/05/09 09:00
CRDT- 2009/04/18 09:00
PHST- 2009/04/18 09:00 [entrez]
PHST- 2009/04/18 09:00 [pubmed]
PHST- 2009/05/09 09:00 [medline]
AID - 80/5/575 [pii]
AID - 10.1136/jnnp.2008.150698 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2009 May;80(5):575-7. doi: 
      10.1136/jnnp.2008.150698.