PMID- 19372690
OWN - NLM
STAT- MEDLINE
DCOM- 20090616
LR  - 20131121
IS  - 1421-9859 (Electronic)
IS  - 0378-5866 (Linking)
VI  - 31
IP  - 1-2
DP  - 2009
TI  - Dissociation between serotonin neurotoxicity and brain-derived neurotrophic 
      factor induction following neonatal MDMA exposure in rats.
PG  - 90-4
LID - 10.1159/000207497 [doi]
AB  - Early developmental treatment of rats with 3,4-methylenedioxymethamphetamine 
      (MDMA) was previously found to cause an abnormal pattern of forebrain 
      serotonergic axon density in adulthood consisting of a cortical hypoinnervation 
      and a striatal hyperinnervation. The present study tested the hypothesis that 
      this reorganization was due to regional differences in brain-derived neurotrophic 
      factor (BDNF) expression. Rats received MDMA (10 mg/kg, s.c., b.i.d.) on 
      postnatal days (PD) 1-4, after which brain tissues were collected on PD 11, 30, 
      and 67 for analysis. BDNF protein levels were found to be elevated in the 
      occipital cortex but not in the hippocampus or striatum following MDMA 
      administration. Serotonin transporter binding (an index of serotonergic fiber 
      integrity) was significantly reduced in the hippocampus at PD 11 but returned to 
      normal by PD 30, whereas the cortex exhibited a delayed reduction that was not 
      manifested until PD 30. These results do not support the view that a 
      region-specific enhancement in BDNF expression mediates the abnormal serotonergic 
      reinnervation observed following neonatal MDMA exposure.
CI  - 2009 S. Karger AG, Basel.
FAU - Piper, Brian J
AU  - Piper BJ
AD  - Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA, USA.
FAU - Farelli, Jeremiah D
AU  - Farelli JD
FAU - Meyer, Jerrold S
AU  - Meyer JS
LA  - eng
GR  - T32 NS007490/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090417
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hallucinogens)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Brain Chemistry/drug effects
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Hallucinogens/*toxicity
MH  - Hippocampus/drug effects/metabolism
MH  - Immunohistochemistry
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neostriatum/drug effects/metabolism
MH  - Nerve Fibers/metabolism
MH  - Neurotoxicity Syndromes/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*physiology
MH  - Serotonin Plasma Membrane Transport Proteins/metabolism
MH  - Up-Regulation/drug effects
EDAT- 2009/04/18 09:00
MHDA- 2009/06/17 09:00
CRDT- 2009/04/18 09:00
PHST- 2008/03/13 00:00 [received]
PHST- 2008/06/07 00:00 [accepted]
PHST- 2009/04/18 09:00 [entrez]
PHST- 2009/04/18 09:00 [pubmed]
PHST- 2009/06/17 09:00 [medline]
AID - 000207497 [pii]
AID - 10.1159/000207497 [doi]
PST - ppublish
SO  - Dev Neurosci. 2009;31(1-2):90-4. doi: 10.1159/000207497. Epub 2009 Apr 17.