PMID- 19376162
OWN - NLM
STAT- MEDLINE
DCOM- 20090817
LR  - 20090602
IS  - 1873-1686 (Electronic)
IS  - 0167-0115 (Linking)
VI  - 155
IP  - 1-3
DP  - 2009 Jun 5
TI  - Interstitial concentrations of adipokines in subcutaneous abdominal and femoral 
      adipose tissue.
PG  - 39-45
LID - 10.1016/j.regpep.2009.04.010 [doi]
AB  - Adipokines play important regulatory roles in the pathophysiology of obesity and 
      insulin resistance. We measured plasma and interstitial concentrations of the 
      adipokines adiponectin, resistin, leptin, monocyte chemoattractant protein-1 
      (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) in subcutaneous, abdominal 
      and femoral adipose tissue using calibrated, large-pore microdialysis technique 
      in 8 healthy, lean men on 2 experimental days. The interstitial leptin 
      concentration was 2.5-fold higher in subcutaneous, femoral than abdominal adipose 
      tissue (P<0.05), but no regional differences were found for the remaining 
      adipokines (P>0.05). Adiponectin and leptin concentrations were higher in plasma 
      than subcutaneous adipose tissue (approximately 25-fold and approximately 2-fold, 
      respectively, P<0.05), whereas MCP-1, IL-6 and IL-8 concentrations were higher in 
      subcutaneous adipose tissue than plasma (approximately 100-fold, approximately 
      200-fold and approximately 1000-fold, respectively, P<0.05). Resistin 
      concentrations did not differ significantly between compartments. Adipose tissue 
      blood flow (ATBF) showed no regional difference (P>0.05). The intra- and 
      inter-subject variations of all investigated adipokines as well as of ATBF were 
      substantial (coefficient of variation: 4-177%). In conclusion, interstitial 
      leptin concentrations are approximately 2.5-fold higher in subcutaneous, femoral 
      than abdominal adipose tissue, which might be a potential mechanism behind the 
      health-benefits of "pear-shape". Furthermore, subcutaneous adipose tissue has a 
      marked production of pro-inflammatory adipokines.
FAU - Nielsen, Ninna Bo
AU  - Nielsen NB
AD  - Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen 
      N, Denmark.
FAU - Hojbjerre, Lise
AU  - Hojbjerre L
FAU - Sonne, Mette P
AU  - Sonne MP
FAU - Alibegovic, Amra C
AU  - Alibegovic AC
FAU - Vaag, Allan
AU  - Vaag A
FAU - Dela, Flemming
AU  - Dela F
FAU - Stallknecht, Bente
AU  - Stallknecht B
LA  - eng
PT  - Journal Article
DEP - 20090417
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Adipokines)
RN  - 0 (Adiponectin)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Leptin)
RN  - 0 (Resistin)
SB  - IM
MH  - Abdominal Fat/blood supply/*metabolism
MH  - Adipokines/*metabolism
MH  - Adiponectin/metabolism
MH  - Adult
MH  - Chemokine CCL2/metabolism
MH  - Femur/*metabolism
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Interleukin-8/metabolism
MH  - Leptin/metabolism
MH  - Male
MH  - Microdialysis
MH  - Resistin/metabolism
MH  - Subcutaneous Fat/blood supply/*metabolism
MH  - Young Adult
EDAT- 2009/04/21 09:00
MHDA- 2009/08/18 09:00
CRDT- 2009/04/21 09:00
PHST- 2008/08/24 00:00 [received]
PHST- 2009/02/24 00:00 [revised]
PHST- 2009/04/05 00:00 [accepted]
PHST- 2009/04/21 09:00 [entrez]
PHST- 2009/04/21 09:00 [pubmed]
PHST- 2009/08/18 09:00 [medline]
AID - S0167-0115(09)00084-6 [pii]
AID - 10.1016/j.regpep.2009.04.010 [doi]
PST - ppublish
SO  - Regul Pept. 2009 Jun 5;155(1-3):39-45. doi: 10.1016/j.regpep.2009.04.010. Epub 
      2009 Apr 17.