PMID- 19379453
OWN - NLM
STAT- MEDLINE
DCOM- 20090804
LR  - 20161125
IS  - 1751-7133 (Electronic)
IS  - 1527-5299 (Linking)
VI  - 15
IP  - 2
DP  - 2009 Mar-Apr
TI  - Prognostic value of natriuretic peptides in Chagas' disease: a head-to-head 
      comparison of the 3 natriuretic peptides.
PG  - 75-81
LID - 10.1111/j.1751-7133.2009.00051.x [doi]
AB  - To determine the diagnostic and prognostic value of natriuretic peptides in 
      patients with Chagas' disease (CD), the authors first measured atrial (ANP), 
      B-type (BNP), and C-type natriuretic peptide (CNP) and compared their diagnostic 
      and prognostic capacity with that in other dilated cardiomyopathies (DCM). The CD 
      and DCM patients were subdivided according to their New York Heart Association 
      (NYHA) classification. Circulating ANP and more pronounced BNP, but not CNP, were 
      increased in CD and DCM patients in relation to NYHA class. Importantly, ANP and 
      BNP were already significantly elevated in CD patients without systolic 
      ventricular dysfunction. All 3 natriuretic peptides were correlated with 
      echocardiographic parameters in CD patients. While ANP and BNP have high 
      predictive value for mortality and necessity for heart transplant in CD, CNP can 
      not predict them. Thus, ANP and BNP rather than CNP could be used as valuable 
      molecular markers to identify asymptomatic CD patients for early therapy and 
      predict clinical outcomes.
FAU - Moreira, Maria da Consolacao V
AU  - Moreira Mda C
AD  - Department of Internal Medicine, UFMG, Belo Horizonte, Brazil.
FAU - Wang, Yong
AU  - Wang Y
FAU - Heringer-Walther, Silvia
AU  - Heringer-Walther S
FAU - Wessel, Niels
AU  - Wessel N
FAU - Walther, Thomas
AU  - Walther T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Congest Heart Fail
JT  - Congestive heart failure (Greenwich, Conn.)
JID - 9714174
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 127869-51-6 (Natriuretic Peptide, C-Type)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Adult
MH  - Atrial Natriuretic Factor/*blood
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Dilated/blood/diagnostic imaging/mortality
MH  - Chagas Cardiomyopathy/*blood/diagnostic imaging/mortality
MH  - Cohort Studies
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/blood/diagnostic imaging
MH  - Heart Transplantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Natriuretic Peptide, C-Type/*blood
MH  - Prognosis
MH  - Prospective Studies
MH  - Statistics as Topic
MH  - Survival Rate
MH  - Ventricular Dysfunction, Left/blood/diagnostic imaging/mortality
EDAT- 2009/04/22 09:00
MHDA- 2009/08/06 09:00
CRDT- 2009/04/22 09:00
PHST- 2009/04/22 09:00 [entrez]
PHST- 2009/04/22 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
AID - CHF051 [pii]
AID - 10.1111/j.1751-7133.2009.00051.x [doi]
PST - ppublish
SO  - Congest Heart Fail. 2009 Mar-Apr;15(2):75-81. doi: 
      10.1111/j.1751-7133.2009.00051.x.