PMID- 19379551
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 17
IP  - 2
DP  - 2009 Apr
TI  - [Deletions of derivative chromosome 9 in 138 patients with chronic myeloid 
      leukemia].
PG  - 281-4
AB  - To investigate the frequency of derivative chromosome 9 [der (9)] deletions in 
      patients with chronic myelogenous leukemia (CML), karyotype analysis in 138 
      patients with CML was performed with R-banding technique, and dual fusion 
      fluorescence in situ hybridization (FISH) was used to detect der (9) deletion. 
      The results showed that among 138 cases, 126 cases were Ph positive (91.3%) from 
      which 122 cases were typical Ph translocation, 12 cases were Ph negative (8.7%). 
      FISH detection revealed 23 with der (9) deletions out of 138 cases (16.7%), 20 
      out of 122 cases with typical Ph translocation showed typical Ph translocation 
      (16.4%) and 3 out of 4 cases with variant Ph translocation had variant Ph 
      translocation (75%). 20 cases were in chronic phase (CP) (17.2%), 3 cases were in 
      blast crisis (BC) (17.6%), there was no significant difference in the frequency 
      of the der (9) deletions between the cases in CP and in BC (p < 0.05). It is 
      concluded that incidence of der (9) partial deletions in CML patients is 16.7%, 
      FISH can effectively detect the der (9) deletions, and there is no correlation of 
      der (9) deletion frequency between cases in different phases of CML.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Hematology, Nanjing Medical University, Jiangsu Provincial 
      Hospital, Nanjing 210029, Jiangsu Province, China.
FAU - Qian, Si-Xuan
AU  - Qian SX
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Wang, Rong
AU  - Wang R
FAU - Zhang, Su-Jiang
AU  - Zhang SJ
FAU - Miao, Kou-Rong
AU  - Miao KR
FAU - Fan, Lei
AU  - Fan L
FAU - Xu, Wei
AU  - Xu W
FAU - Li, Jian-Yong
AU  - Li JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Sequence Deletion
MH  - Young Adult
EDAT- 2009/04/22 09:00
MHDA- 2011/07/13 06:00
CRDT- 2009/04/22 09:00
PHST- 2009/04/22 09:00 [entrez]
PHST- 2009/04/22 09:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 1009-2137(2009)02-0281-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):281-4.