PMID- 19382262
OWN - NLM
STAT- MEDLINE
DCOM- 20090608
LR  - 20091119
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 81
IP  - 6
DP  - 2009 Jun
TI  - Association of IL-4 589 C/T promoter and IL-4RalphaI50V receptor polymorphism 
      with susceptibility to HIV-1 infection in North Indians.
PG  - 959-65
LID - 10.1002/jmv.21478 [doi]
AB  - The clinical course and outcome of HIV-1 infection are highly variable among 
      individuals. Interleukin 4 (IL-4) is a key T helper 2 cytokine with various 
      immune-modulating functions including induction of immunoglobulin E (IgE) 
      production in B cells, downregulation of CCR5 and upregulation of CXCR4, the main 
      co-receptors for HIV. Our objective is to investigate whether single-nucleotide 
      polymorphisms (SNPs) in the IL-4 promoter 589 C/T and IL-4 Ralpha I50V affect the 
      susceptibility to HIV infection and its progression to AIDS in North Indian 
      individuals. The study population consisted of 180 HIV-1 seropositive (HSP) 
      stratified on the basis of disease severity (stage I, II, III), 50 HIV-1 exposed 
      seronegative (HES), and 305 HIV-1 seronegative (HSN) individuals. The subjects 
      were genotyped for IL-4 589 C/T promoter polymorphism and IL-4 Ralpha I50V by 
      polymerase chain reaction restriction fragment length polymorphism. The results 
      showed that IL-4 589 C/T was not associated with the risk of HIV infection and 
      disease progression. However, the IL-4Ralpha I50 allele and genotype was 
      significantly increased in HSP compared to HSN and HSP and was associated with 
      risk of HIV infection. The frequency of IL-4Ralpha I50 allele in the HSP group 
      was higher than in HSN (76.11 vs. 64.75%; P = 0.000; OR = 1.734) and HES (76.11% 
      vs. 62.00%; P = 0.007; OR = 1.953). Homozygous IL-4Ralpha I50I genotype was 
      significantly increased in HSP group compared with HSN (58.88% vs. 44.26%; P = 
      0.002; OR = 1.804) and HES (58.88% vs. 42.00%; P = 0.038; OR = 1.978). The 
      present study for the first time suggests an association of IL-4Ralpha I50 allele 
      with increased likelihood of HIV-1 infection in North Indian population. Further 
      studies are required to confirm these findings and understand the effect of 
      IL-4Ralpha polymorphism on the outcome of HIV-1 infection.
FAU - Chatterjee, Animesh
AU  - Chatterjee A
AD  - Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Lucknow, India.
FAU - Rathore, Anurag
AU  - Rathore A
FAU - Dhole, Tapan N
AU  - Dhole TN
LA  - eng
SI  - RefSeq/NM_000418
SI  - RefSeq/NM_000589
SI  - RefSeq/NM_001008699
SI  - RefSeq/NM_172348
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Receptors, Interleukin-4)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Testing
MH  - HIV Infections/*genetics
MH  - Humans
MH  - India
MH  - Interleukin-4/*genetics
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin-4/*genetics
MH  - Sequence Analysis, DNA
EDAT- 2009/04/22 09:00
MHDA- 2009/06/09 09:00
CRDT- 2009/04/22 09:00
PHST- 2009/04/22 09:00 [entrez]
PHST- 2009/04/22 09:00 [pubmed]
PHST- 2009/06/09 09:00 [medline]
AID - 10.1002/jmv.21478 [doi]
PST - ppublish
SO  - J Med Virol. 2009 Jun;81(6):959-65. doi: 10.1002/jmv.21478.