PMID- 19383117
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20090617
LR  - 20211020
IS  - 1742-6405 (Electronic)
IS  - 1742-6405 (Linking)
VI  - 6
DP  - 2009 Apr 21
TI  - Is vitamin D deficiency involved in the immune reconstitution inflammatory 
      syndrome?
PG  - 4
LID - 10.1186/1742-6405-6-4 [doi]
AB  - BACKGROUND: About 20-30% of persons with HIV infection, especially those living 
      in countries with limited resources, experience an immune reconstitution 
      inflammatory syndrome (IRIS) after starting antiretroviral treatment. The active 
      form of vitamin D, 1,25-dihydroxyvitamin D, is a key player in the clearance of 
      pathogens and influences the level of inflammation and macrophage activation. 
      PRESENTATION OF THE HYPOTHESIS: We hypothesize that low availability of 
      1,25-dihydroxyvitamin D, either due to vitamin D deficiency or due to 
      polymorphisms in the vitamin D receptor or in its activating/inactivating 
      enzymes, contributes to the appearance of IRIS. Furthermore, drug interactions 
      with the enzymatic pathways of vitamin D could favour the development of IRIS. 
      TESTING THE HYPOTHESIS: Our hypothesis could be explored by a case-control study 
      to assess the prevalence of vitamin D deficiency in HIV-infected patients on 
      antiretroviral treatment who develop and do not develop IRIS. IMPLICATIONS OF THE 
      HYPOTHESIS: If the role of vitamin D in IRIS is confirmed, we would be able to 
      screen patients at risk for IRIS by screening for vitamin D deficiency. After 
      confirmation by means of a clinical trial, vitamin D supplementation could be a 
      cheap and safe way to reduce the incidence of IRIS.
FAU - Conesa-Botella, Anali
AU  - Conesa-Botella A
AD  - Institute of Tropical Medicine, Department of Clinical Sciences, Antwerp, 
      Belgium. aconesa@itg.be
FAU - Mathieu, Chantal
AU  - Mathieu C
FAU - Colebunders, Robert
AU  - Colebunders R
FAU - Moreno-Reyes, Rodrigo
AU  - Moreno-Reyes R
FAU - van Etten, Evelyne
AU  - van Etten E
FAU - Lynen, Lut
AU  - Lynen L
FAU - Kestens, Luc
AU  - Kestens L
LA  - eng
PT  - Journal Article
DEP - 20090421
PL  - England
TA  - AIDS Res Ther
JT  - AIDS research and therapy
JID - 101237921
PMC - PMC2678152
EDAT- 2009/04/23 09:00
MHDA- 2009/04/23 09:01
PMCR- 2009/04/21
CRDT- 2009/04/23 09:00
PHST- 2009/02/13 00:00 [received]
PHST- 2009/04/21 00:00 [accepted]
PHST- 2009/04/23 09:00 [entrez]
PHST- 2009/04/23 09:00 [pubmed]
PHST- 2009/04/23 09:01 [medline]
PHST- 2009/04/21 00:00 [pmc-release]
AID - 1742-6405-6-4 [pii]
AID - 10.1186/1742-6405-6-4 [doi]
PST - epublish
SO  - AIDS Res Ther. 2009 Apr 21;6:4. doi: 10.1186/1742-6405-6-4.