PMID- 19383672 OWN - NLM STAT- MEDLINE DCOM- 20090901 LR - 20220408 IS - 1388-9842 (Print) IS - 1388-9842 (Linking) VI - 11 IP - 6 DP - 2009 Jun TI - Patterns of late gadolinium enhancement are associated with ventricular stiffness in patients with advanced non-ischaemic dilated cardiomyopathy. PG - 573-80 LID - 10.1093/eurjhf/hfp050 [doi] AB - AIMS: Despite the prognostic importance of ventricular filling and ventricular-arterial interaction in patients with advanced systolic heart failure, the structural determinants of these parameters have not been fully studied. We aimed to investigate whether patterns of late gadolinium enhancement (LGE) on cardiac magnetic resonance affect ventricular elastic properties or performance in patients with non-ischaemic dilated cardiomyopathy (DCM). METHODS AND RESULTS: Patients (n = 49) with markedly reduced systolic function (left ventricular (LV) ejection fraction <35%) due to longstanding non-ischaemic DCM underwent contrast-enhanced cardiac magnetic resonance after comprehensive echo-Doppler evaluations. The single beat-derived end-diastolic elastance, end-systolic elastance, arterial elastance, and dyssynchrony indices were measured by echo. On the basis of LGE patterns, patients could be divided into three groups: non-LGE (n = 18), non-midwall LGE (n = 13), and midwall LGE (n = 18). The midwall LGE group had lower LV systolic longitudinal velocity (4.6 +/- 1.7 for non-LGE vs. 4.3 +/- 1.2 for non-midwall LGE vs. 3.5 +/- 1.0 cm/s for midwall LGE, P = 0.025), higher end-diastolic elastance index (0.41 +/- 0.21 vs. 0.46 +/- 0.31 vs. 0.85 +/- 0.51 respectively, P = 0.008), and a more impaired ventriculoarterial coupling index (3.14 +/- 1.53 vs. 2.88 +/- 1.94 vs. 5.52 +/- 3.18, P = 0.006) than other subgroups. CONCLUSION: Patients with midwall LGE had a higher ventricular stiffness index and more impaired ventriculoarterial coupling when compared with other non-ischaemic DCM patients. FAU - Choi, Eui-Young AU - Choi EY AD - Cardiology Division, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Shinchon-dong 134, Seoul, South Korea 120-752. FAU - Choi, Byoung Wook AU - Choi BW FAU - Kim, Sung-Ai AU - Kim SA FAU - Rhee, Sang Jae AU - Rhee SJ FAU - Shim, Chi Young AU - Shim CY FAU - Kim, Young Jin AU - Kim YJ FAU - Kang, Seok-Min AU - Kang SM FAU - Ha, Jong-Won AU - Ha JW FAU - Chung, Namsik AU - Chung N LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090421 PL - England TA - Eur J Heart Fail JT - European journal of heart failure JID - 100887595 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Cardiomyopathy, Dilated/*diagnosis/physiopathology MH - Contrast Media/*adverse effects MH - Echocardiography, Doppler MH - Elasticity/drug effects MH - Female MH - Follow-Up Studies MH - Gadolinium DTPA/*adverse effects MH - Heart Ventricles/diagnostic imaging/pathology/*physiopathology MH - Humans MH - Magnetic Resonance Angiography/adverse effects/*methods MH - Male MH - Middle Aged MH - Myocardial Contraction/*drug effects MH - Prospective Studies MH - Risk Factors EDAT- 2009/04/23 09:00 MHDA- 2009/09/02 06:00 CRDT- 2009/04/23 09:00 PHST- 2009/04/23 09:00 [entrez] PHST- 2009/04/23 09:00 [pubmed] PHST- 2009/09/02 06:00 [medline] AID - hfp050 [pii] AID - 10.1093/eurjhf/hfp050 [doi] PST - ppublish SO - Eur J Heart Fail. 2009 Jun;11(6):573-80. doi: 10.1093/eurjhf/hfp050. Epub 2009 Apr 21.