PMID- 19383973
OWN - NLM
STAT- MEDLINE
DCOM- 20090918
LR  - 20211203
IS  - 1937-9145 (Electronic)
IS  - 1945-0877 (Linking)
VI  - 2
IP  - 67
DP  - 2009 Apr 21
TI  - Focus Issue: demystifying mTOR signaling.
PG  - eg5
LID - 10.1126/scisignal.267eg5 [doi]
AB  - The mammalian target of rapamycin (mTOR) is a master integrator of cell energy 
      state, nutrient status, and growth factor stimulation. This kinase is part of two 
      distinct complexes, mTORC1 and mTORC2, and the network that regulates these two 
      complexes is interconnected with distinct and overlapping inputs and outputs. 
      Research published in Science Signaling has revealed new connections between 
      epidermal growth factor receptors and the mTOR pathway, and new insight into the 
      roles of mTOR signaling in vascular disease. The Perspectives in this issue 
      highlight how new pharmacological tools and the ability to knock down the 
      function of complex-specific subunits are providing new insight into the 
      regulation and functions of these complexes in physiological contexts, as well as 
      providing new avenues for therapeutic intervention in diseases associated with 
      aberrant activity of these complexes.
FAU - Gough, Nancy R
AU  - Gough NR
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
DEP - 20090421
PL  - United States
TA  - Sci Signal
JT  - Science signaling
JID - 101465400
RN  - 0 (Immunosuppressive Agents)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunosuppressive Agents/pharmacology
MH  - Protein Kinases/*metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases
EDAT- 2009/04/23 09:00
MHDA- 2009/09/19 06:00
CRDT- 2009/04/23 09:00
PHST- 2009/04/23 09:00 [entrez]
PHST- 2009/04/23 09:00 [pubmed]
PHST- 2009/09/19 06:00 [medline]
AID - scisignal.267eg5 [pii]
AID - 10.1126/scisignal.267eg5 [doi]
PST - epublish
SO  - Sci Signal. 2009 Apr 21;2(67):eg5. doi: 10.1126/scisignal.267eg5.