PMID- 19386542
OWN - NLM
STAT- MEDLINE
DCOM- 20090630
LR  - 20090512
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 120
IP  - 5
DP  - 2009 May
TI  - Auditory discrimination profiles of speech sound changes in 6-year-old children 
      as determined with the multi-feature MMN paradigm.
PG  - 916-21
LID - 10.1016/j.clinph.2009.03.010 [doi]
AB  - OBJECTIVE: A linguistic multi-feature mismatch negativity (MMN) paradigm with 
      five types of changes (vowel, vowel-duration, consonant, frequency (F0), and 
      intensity) in Finnish syllables was used to determine speech-sound discrimination 
      in 17 normally-developing 6-year-old children. The MMNs for vowel and 
      vowel-duration were also recorded in an oddball condition in order to compare the 
      two paradigms. Similar MMNs in the two paradigms would suggest that they tap the 
      same processes. This would promote the usefulness of the more time-efficient 
      multi-feature paradigm for future studies in children. METHODS: MMNs to five 
      deviant types were recorded in the multi-feature paradigm in which these deviants 
      (total of 50%) were presented in an alternating fashion with standards (50%). An 
      oddball condition with vowel and vowel-duration deviants served as a control. 
      RESULTS: The linguistic multi-feature paradigm elicited significant MMN responses 
      to all changes used and the responses were comparable to the ones recorded with 
      the traditional oddball paradigm. Compared to a previous adult study (Pakarinen 
      S, Lovio R, Huotilainen M, Alku P, Naatanen R, Kujala T. Fast multi-feature 
      paradigm for recording several mismatch negativities (MMNs) to phonetic and 
      acoustic changes in speech sounds. Biol Psychol, submitted for publication), the 
      MMN amplitudes seemed to be smaller and of longer latencies in general in 
      children than in adults. CONCLUSIONS: The new time-efficient paradigm can be used 
      in studies addressing cortical speech-sound discrimination in young children. 
      SIGNIFICANCE: The multi-feature paradigm enables fast (20 min) recording of MMNs 
      for five speech-sound features. In future, it might be useful in detecting 
      abnormalities in speech discrimination profiles of children with possible 
      language-related disorders.
FAU - Lovio, Riikka
AU  - Lovio R
AD  - Department of Psychology, Cognitive Brain Research Unit, University of Helsinki, 
      P.O. Box 9, Helsinki 00014, Finland. riikka.lovio@helsinki.fi
FAU - Pakarinen, Satu
AU  - Pakarinen S
FAU - Huotilainen, Minna
AU  - Huotilainen M
FAU - Alku, Paavo
AU  - Alku P
FAU - Silvennoinen, Salla
AU  - Silvennoinen S
FAU - Naatanen, Risto
AU  - Naatanen R
FAU - Kujala, Teija
AU  - Kujala T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090421
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Acoustic Stimulation
MH  - Aging/physiology
MH  - Brain Mapping
MH  - Cerebral Cortex/*growth & development
MH  - Child
MH  - Electroencephalography/*methods
MH  - Female
MH  - Finland
MH  - Humans
MH  - *Language
MH  - Language Tests
MH  - Learning/*physiology
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Pitch Discrimination/physiology
MH  - Speech Perception/*physiology
EDAT- 2009/04/24 09:00
MHDA- 2009/07/01 09:00
CRDT- 2009/04/24 09:00
PHST- 2008/08/19 00:00 [received]
PHST- 2009/03/11 00:00 [revised]
PHST- 2009/03/18 00:00 [accepted]
PHST- 2009/04/24 09:00 [entrez]
PHST- 2009/04/24 09:00 [pubmed]
PHST- 2009/07/01 09:00 [medline]
AID - S1388-2457(09)00281-8 [pii]
AID - 10.1016/j.clinph.2009.03.010 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2009 May;120(5):916-21. doi: 10.1016/j.clinph.2009.03.010. 
      Epub 2009 Apr 21.