PMID- 19387654
OWN - NLM
STAT- MEDLINE
DCOM- 20091222
LR  - 20211020
IS  - 1433-0350 (Electronic)
IS  - 0256-7040 (Linking)
VI  - 25
IP  - 11
DP  - 2009 Nov
TI  - Cytogenetic findings in a rare pediatric mixed glioneuronal tumor and review of 
      the literature.
PG  - 1485-90
LID - 10.1007/s00381-009-0896-5 [doi]
AB  - OBJECTIVE: The aim of the present study was to report the chromosomal 
      abnormalities findings in rare pediatric mixed glioneuronal tumor (GNT), which 
      could not be classified according to the WHO classification. METHODS: Cytogenetic 
      studies were performed using G-banding and fluorescence in situ hybridization 
      (FISH) techniques. RESULTS: Cytogenetic analyses showed a deletion of 1p as 
      primary genetic event and gain of chromosome 7 as secondary change. Furthermore, 
      we present a review of available cytogenetic data of 72 pediatric patients with 
      GNT. Taken into account these data and the present case, we found that the most 
      frequent chromosomal anomalies involved gains of chromosomes 7 (15.1%), 5 (8.2%), 
      1q32-qter (6.8%), 8p21-qter (6.8%), 12 (5.5%), 18 (5.5%), 20q11-qter (5.5%), and 
      X (5.5%). Frequent losses were detected on chromosome regions 1p (8.2%) and 22q 
      (5.5%). CONCLUSION: The findings of our case combined with those of previous 
      reports suggest that chromosomes 1 and 7 may contain candidate genes involved in 
      the tumorigenesis of GNT.
FAU - Cocce, Mariela C
AU  - Cocce MC
AD  - Cytogenetics Laboratory, Genetics Department, Garrahan Pediatrics Hospital, 
      Buenos Aires, Argentina. marielacocce@yahoo.com.ar
FAU - Lubieniecki, Fabiana
AU  - Lubieniecki F
FAU - Bartuluchi, Marcelo
AU  - Bartuluchi M
FAU - Gallego, Marta S
AU  - Gallego MS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20090422
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for 
      Pediatric Neurosurgery
JID - 8503227
SB  - IM
MH  - Adolescent
MH  - Brain Neoplasms/*genetics/pathology/surgery
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 7
MH  - Cytogenetic Analysis
MH  - Female
MH  - Glioma/*genetics/pathology/surgery
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Magnetic Resonance Imaging
MH  - Neoplasms, Nerve Tissue/*genetics/pathology/surgery
MH  - Sequence Deletion
MH  - Treatment Outcome
RF  - 27
EDAT- 2009/04/24 09:00
MHDA- 2009/12/23 06:00
CRDT- 2009/04/24 09:00
PHST- 2009/02/02 00:00 [received]
PHST- 2009/03/19 00:00 [revised]
PHST- 2009/04/24 09:00 [entrez]
PHST- 2009/04/24 09:00 [pubmed]
PHST- 2009/12/23 06:00 [medline]
AID - 10.1007/s00381-009-0896-5 [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2009 Nov;25(11):1485-90. doi: 10.1007/s00381-009-0896-5. Epub 
      2009 Apr 22.