PMID- 19388013
OWN - NLM
STAT- MEDLINE
DCOM- 20091123
LR  - 20211020
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 150B
IP  - 6
DP  - 2009 Sep 5
TI  - BDNF, relative preference, and reward circuitry responses to emotional 
      communication.
PG  - 762-81
LID - 10.1002/ajmg.b.30944 [doi]
AB  - Brain derived neurotrophic factor (BDNF) regulates neural development and 
      synaptic transmission. We have tested the hypothesis that functional variation in 
      the BDNF gene (Val66Met polymorphism, rs6265) affects brain reward circuitry 
      encoding human judgment and decision-making regarding relative preference. We 
      quantified relative preference among faces with emotional expressions (angry, 
      fearful, sad, neutral, and happy) by a keypress procedure performed offline to 
      measure effort traded for viewing time. Keypress-based relative preferences 
      across the ensemble of faces were mirrored significantly by fMRI signal in the 
      orbitofrontal cortex, amygdala, and hippocampus when passively viewing these 
      faces. For these three brain regions, there was also a statistically significant 
      group difference by BDNF genotype in the fMRI responses to the emotional 
      expressions. In comparison with Val/Met heterozygotes, Val/Val individuals 
      preferentially sought exposure to positive emotions (e.g., happy faces) and had 
      stronger regional fMRI activation to aversive stimuli (e.g., angry, fearful, and 
      sad faces). BDNF genotype accounted for approximately 30% of the variance in fMRI 
      signal that mirrors keypress responses to these stimuli. This study demonstrates 
      that functional allelic variation in BDNF modulates human brain circuits 
      processing reward/aversion information and relative preference transactions.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Gasic, G P
AU  - Gasic GP
AD  - Motivation and Emotion Neuroscience Collaboration (MENC), Department of 
      Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 
      Massachusetts, USA.
FAU - Smoller, J W
AU  - Smoller JW
FAU - Perlis, R H
AU  - Perlis RH
FAU - Sun, M
AU  - Sun M
FAU - Lee, S
AU  - Lee S
FAU - Kim, B W
AU  - Kim BW
FAU - Lee, M J
AU  - Lee MJ
FAU - Holt, D J
AU  - Holt DJ
FAU - Blood, A J
AU  - Blood AJ
FAU - Makris, N
AU  - Makris N
FAU - Kennedy, D K
AU  - Kennedy DK
FAU - Hoge, R D
AU  - Hoge RD
FAU - Calhoun, J
AU  - Calhoun J
FAU - Fava, M
AU  - Fava M
FAU - Gusella, J F
AU  - Gusella JF
FAU - Breiter, H C
AU  - Breiter HC
LA  - eng
GR  - P20 DA026002/DA/NIDA NIH HHS/United States
GR  - 14118/PHS HHS/United States
GR  - M01 RR001066/RR/NCRR NIH HHS/United States
GR  - R01 DA014118/DA/NIDA NIH HHS/United States
GR  - R33 DA026104/DA/NIDA NIH HHS/United States
GR  - P41RR14075/RR/NCRR NIH HHS/United States
GR  - P41 RR014075/RR/NCRR NIH HHS/United States
GR  - 34189/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Amygdala/physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - *Decision Making
MH  - Emotions/*physiology
MH  - *Facial Expression
MH  - Female
MH  - Frontal Lobe/physiology
MH  - Genotype
MH  - Hippocampus/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Polymorphism, Genetic
MH  - *Reward
PMC - PMC7891456
MID - NIHMS506498
EDAT- 2009/04/24 09:00
MHDA- 2009/12/16 06:00
PMCR- 2021/02/18
CRDT- 2009/04/24 09:00
PHST- 2009/04/24 09:00 [entrez]
PHST- 2009/04/24 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2021/02/18 00:00 [pmc-release]
AID - 10.1002/ajmg.b.30944 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 5;150B(6):762-81. doi: 
      10.1002/ajmg.b.30944.