PMID- 19388300
OWN - NLM
STAT- MEDLINE
DCOM- 20090610
LR  - 20190917
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 102
DP  - 2008
TI  - Noninvasive estimation of intracranial compliance in idiopathic NPH using MRI.
PG  - 115-8
AB  - BACKGROUND: The pathophysiology of idiopathic normal pressure hydrocephalus 
      (I-NPH) is still unclear and the diagnosis is sometimes difficult. The aim of 
      this study was to assess the biophysics of I-NPH by measuring intracranial 
      compliance using cine MRI. METHODS: The study included patients with I-NPH (I-NPH 
      group, n = 13), brain atrophy or asymptomatic ventricular dilation (VD group, n = 
      10), and healthy volunteers (control group, n = 13). Net blood flow (bilateral 
      internal carotid and vertebral arteries and jugular veins) and cerebrospinal 
      fluid (CSF) flow in the subarachnoid space at the C2 cervical vertebral level 
      were measured using phase-contrast cine MRI. CSF pressure gradient (PG(p-p)) and 
      intracranial volume changes (VC(p-p)) during a cardiac cycle were calculated. 
      FINDINGS: The compliance index (CI=VC(p-p)/PG(p-p)) in the I-NPH group was 
      significantly lower than in the control and VD groups, whereas no difference was 
      found between the control and VD groups. CI values of I-NPH patients after the 
      tap test were larger than those before. These results clearly show that the 
      intracranial compliance of I-NPH is relatively low compared to that of brain 
      atrophy or normal subject. The increase of CI after a tap test also supports this 
      finding. CONCLUSIONS: It is possible to estimate intracranial compliance as CI 
      non-invasively using cine MRI. CI could become a useful method for the diagnosis 
      of I-NPH.
FAU - Mase, Mitsuhito
AU  - Mase M
AD  - Department of Neurosurgery and Restorative Neuroscience, Graduate School of 
      Medical Sciences, Nagoya City University, 1-Kawasumi, Mizuho-cho, Mizuho-ku, 
      Nagoya 467-8602, Japan. mitmase@med.nagoya-cu.ac.jp
FAU - Miyati, Toshiaki
AU  - Miyati T
FAU - Kasai, Harumasa
AU  - Kasai H
FAU - Demura, Koichiro
AU  - Demura K
FAU - Osawa, Tomoshi
AU  - Osawa T
FAU - Hara, Masaki
AU  - Hara M
FAU - Shibamoto, Yuta
AU  - Shibamoto Y
FAU - Yamada, Kazuo
AU  - Yamada K
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
SB  - IM
MH  - Atrophy/diagnosis/physiopathology
MH  - Biophysics
MH  - Brain/pathology
MH  - Cerebrospinal Fluid Pressure/*physiology
MH  - Cerebrovascular Circulation
MH  - Compliance
MH  - Dilatation, Pathologic/diagnosis
MH  - Humans
MH  - Hydrocephalus, Normal Pressure/*diagnosis/*physiopathology
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Ventricular Dysfunction/diagnosis/physiopathology
EDAT- 2008/01/01 00:00
MHDA- 2009/06/11 09:00
CRDT- 2009/04/25 09:00
PHST- 2009/04/25 09:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2009/06/11 09:00 [medline]
AID - 10.1007/978-3-211-85578-2_23 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 2008;102:115-8. doi: 10.1007/978-3-211-85578-2_23.